Aim & Objective: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder characterized by symmetrical synovitis, progressive damage to the articular cartilage and the subchondral bone ⁽¹⁾, as well as pain, fatigue, and disability ⁽²⁾.The purpose of this study was to investigate any significant correlation in the level of Lipid profile  and its association with severity of Rheumatoid arthritis

Material and Methods: Total 100 study subjects were divided into two groups, group A comprising 50 apparently healthy controls and group B comprising 50 patients of rheumatoid arthritis, which is further divided into subgroups on the basis of DAS 28 Score, group B1- remission, group B-2 included mild cases of rheumatoid arthritis, group B-3 of moderate & group B-4 of severe cases of rheumatoid arthritis.  Subjects were enrolled after applying all inclusion and exclusion criteria and written informed consent were taken. Serum Lipid profile p estimation were done by Transasia XL-640 Automated analyzer.

Results: The mean triglycerides in the control group was 121.28 ± 21.96 mg/dL while in the rheumatoid arthritis group was 156.32 ± 63.58 mg/dL. The mean VLDL in the control group was 24.26 ± 4.39 mg/dL while in the rheumatoid arthritis group was 31.26 ± 12.72 mg/dL. The difference was found to be statistically significant (p<0.05), showing a higher Triglycerides & VLDL in the rheumatoid arthritis group in comparison to the control group.

Conclusion: Patients with RA and chronic systemic inflammation have altered lipoprotein and apolipoprotein levels that may contribute to their higher risk of atherosclerosis

Keywords:Rheumatoid arthritis ,Triglyceride ,VLDL,Lipid profile.

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Rohit Manyal

Department of Biochemistry, MGM Medical College Indore, MP, India