Title: Dose Adjustment in Renal Failure
Authors: Greeshma B Susan, Albert Thomas, Anjana Peter, Rosemary B Vadakkan, L Panayappan, Grace Thomas, K Krishnakumar
DOI: https://dx.doi.org/10.18535/jmscr/v7i6.105
Abstract
The effect of a drug can be altered due to renal diseases. This is usually due to inefficient clearance of renally excreting drugs from the body. Pharmacokinetic parameters such as bioavailability, volume of distribution, protein binding, and biotransformation of a drug can also be altered in kidney diseases. Hence adjustment of dose according to renal clearance is important .Creatinine clearance is one of those parameters that help to assess the renal function. It can be estimated with Cockcroft- gault equation. Thus following proper dose adjustment for renally excreting drugs, wecan reduce the chances of drug induced nephrotoxicity.
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