Objective: Present study was conducted to evaluate the trends of Microbial agent in patients with chronic Dacryocystitis and their antimicrobial susceptibility pattern.

Material and Method:  A total of 82 patients with chronic Dacryocystitis were included in the study. From all the patients a total of 82 Swab samples were taken aseptically and received in our department for culture and sensitivity testing. Culture and sensitivity tests were done according to CLSI guidelines.

Result: A total of 72 pure cultures isolated from 82 samples, the most common organism found were Staphylococcus aureus in 32 cases (44.44%) followed by Coagulase Negative Staphylococcus (CONS) in 14 cases (19.44%). Amongst S. aureus isolates, aminoglycoside group of antibiotics i.e. Amikacin, and Tobramycin showed a good sensitivity of 75%, and 81.25%. Against betalactam group of antibiotics like cefazolin (68.7%) and cefotaxime (65.6%) were sensitive. Moxifloxacin showed 100% sensitivity when compared to ciprofloxacin (87.5%). Chloramphenicol was found to be least effective drug with only 53.1% sensitivity. For S. pneumoniae cefotaxime and cefazolin gave a high sensitivity of 100% followed by Moxifloxacin 100%, Ciprofloxacin 83.3% and Chloramphenicol showed a sensitivity of 66.6%. Amongst Gram negative Bacilli (GNB) maximum isolates (100%) were sensitive to Ceftazidime which is a third generation Cephalosporin with a good antipseudomonal activity followed by Cefotaxime(87.5%). Sensitivity to Moxifloxacin was observed in 87.5% isolates compared to 50% sensitivity against Ciprofloxacin. Amikacin and Tobramycin was equal effective in 68.7% of isolates.

Conclusion: Staphylococcus is the major cause in pathogenesis of chronic dacryocystis, and candida albicans in few cases which might to be due to reduced immunity.

Keywords: Staphylococcus aureus, Dacryocystis, Chloramphenical, Lacrimal drainage system.

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Dr Satyendu Sagar

Assistant Professor, Department of Microbiology, Nalanda Medical College, Patna, India