Aim: To compare the association of Upper g.i bleed in patients with chron’s disease on Budesonide and SSRI therapy.

Methods: Total 30 patients of chrons disease were included for the study. Patients of both sexes with age group between 18-40 yrs were included. Patients were divided into two groups. Group I received Budesonide 9mg OD. Group II received SSRI in the dose of 40 mg/day. All patients were cases of chron’s disease. Budesonide 9mg OD were given to patients for remission of chron’s disease and SSRIs are given to patients of chron’s disease associated with depression. Both the drugs were given on daily basis for 6 months.

Result: All 30 patients included in the study were assessed for the presence of upper g.i bleed by G.I endoscopic and non-endoscopic parameters. The no of patients showing presence of upper g.i bleed is more in Group A in comparision to Group B.

Conclusion: Acute upper gastrointenstinal haemorrhage is a common medical emergency and mortality rate remains high as 6-8%.From this study it is concluded that patients of chron’s disease taking budesonide have high incidence of upper g.i bleed in comparision to patients with SSRIs.

Keyword: Upper G.I bleed, Chrons disease, SSRIs, Budesonide,

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Rasmirekha Behera

Department of Pharmacology I.M.S & SUM Hospital Bhubaneswar