Type 2 Diabetes Mellitus (T2DM) is a disorder in which there is inefficient use of insulin hormone, leads to build up of glucose in the blood and eventually ends up with hyperglycemia. The aim of this study was to test the hypothesis of inter-relationship of age, body mass index (BMI), random blood sugar (RBS), Total Cholesterol (TC), Triacylglycerols (TAGs), High Density Lipoproteins cholesterol (HDLc), and Ca in patients with T2DM and also to compare these levels with that of healthy controls. Plasma glucose, serum TC, TAGs, HDLc, and Ca were estimated according to the instructions given in the methods. BMI was significantly higher and also the levels of RBS, TC and TAGs were significantly higher in T2DM patients compared with healthy controls. In addition, total serum Ca level was significantly higher in T2DM patients compared with healthy controls. No significant differences were observed in age and HDLc levels in T2DM patients compared with healthy controls. In the patient group positive correlation was observed between age and TAGs, age and HDLc, RBS and TC, RBS and TAGs, RBS and HDLc. In the control group, we found positive correlation between age and HDLc and a negative correlation between BMI and serum Ca. The authors conclude from the study that alterations in the study parameters in T2DM group are due to hyperglycemia, deficient scavenging action of HDLc and increase in serum calcium. Therefore, in patients with T2DM, any compensation mechanism may become insufficient.

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Dr Prabhakar Singh Bais

Assistant Professor, Head of the Department, Biochemistry Department, MLB Medical College, Jhansi