Background: Pain is main post operative adverse outcome causing patient distress, prolonging hospital stay, and increasing the incidence of admissions after surgery. Study was done to assess and compare the post-operative analgesic efficacy offentanyl, butorphanol, pethidine by intranasal route.

Methods: This study was conducted in the department of Anaesthesiology, Sardar Patel medical college and associated group of Hospitals Bikaner after taking permission from institutional research board. All eligible patients divided into 3 different groups: Fentanyl, Butorphanol & Pethidine administered intra-nasally for post-operative pain management.

Results: Onset of analgesia was less in  group I (fentanyl) 7.6±1.16 than group II (butorphanol) 10.23 ± 1.52 and group III (pethidine)  13.23 ± 2.06.Duration of analgesia was more in  group II (butorphanol) 280 ± 36.17 than group I  (fentanyl) 188  ± 28.06 and group III (pethidine) 187 ± 28.33 and rescue analgesia used in group II (butorphannol)  is less than other groups.  Adverse effect like nausea, vomiting and bitter taste in group II (butorphanol) is less than other groups.

Conclusion: Intranasal instillation of butorphanol can certainly by recommended as a routine technique to improve postoperative analgesia.

Keywords: Butorphanol, Post-Operative Analgesia, Intranasal Administration, Side-Effects.

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Poonam Chand

Resident Doctor,  Dept of Anaesthesiology, Sardar Patel Medical College, & A.G. of P.B.M Hospital, Bikaner