Background: The electrolyte imbalances cause various neurological dysfunction & these electrolyte abnormalities frequently cause seizures AS these ions are important in the normal functioning of nervous system. Seizures are especially common with hypomagnesemia and hypocalcemia.

Objective: To study the serum magnesium and calcium levels in patients with new onset seizures.

Methods: The study was carried out from November 2016 to October 2018 at VSS institute of medical science & research, Burla Sambalpur. The study included 120 cases presented with seizures & 120 controls matched with the cases.

Results: Serum magnesium and calcium levels were low in patients with new onset seizures when compared to controls.

Conclusion: Serum magnesium and calcium level may be used for evaluation of seizures as rapid and timely identification and correction can help to reduce morbidity and mortality associated with seizures due to electrolyte ²disturbances.

Keywords:  Serum, Magnesium, Calcium, Hypomagnesemia, Hypocalcemia, Seizure.

1. Health Organization, Atlas: Epilepsy care in the world. Geneva, Switzerland: World Health Organization: 2005
2. Longo, Fauci, Kasper, Hauser, Jameson, Loscalzo. Harrison’s Pinciples Of Internal Medicine, 20th Edition.ch418: 3050-3068
3. Welt LG, Gitelman H. Disorders of magnesium metabolism. DisMon. 1965;47: 1965:1961–1932
4. Bhagwat VR, Sridhara Rama Rao BS.: electrolytes in epilepsy. Proceedings of 57u' Ann. Conf. of Soc. Biol. Chem.(Ind). 9-12 Oct 1988
5. Riggs   Neurological  manifestations  of  electrolyte  disturbances.  Neurology
6. Sridharan R, Murthy BN. Prevalence and pattern of epilepsy in India. Epilepsia. 1999;40:631–
7. Leonardi M,Ustun TB. The global burden of epilepsy. Epilepsia. 2002;43(Suppl 6):21–
8. Commission on epidemiology and prognosis, the international league against epilepsy (ILAE).Guidelines for epidemiologic studies on epilepsy . Epilepsia . 1993 ; 34:592-596
9. International league against epilepsy classification of seizures 2017
10. Rama Krishna C,. Basha S J, Venkateswara Rao B, Preethi B. “Serum Magnesium Levels in Seizure Disorders”. Jemds. 2014;.35(3) : 9313-9319
11. Chavan V D, Bhagwrat V R, Natheniel S, et al Increased Seizure Frequency and Hypomallnesaemia in Epilepsy. The india practitioner.2004;57(3):155-160
12. Canclas Horaciom et al: Disorders of Magnesium metabolism in epilepsy. J. Neurol Neurosurg Psychiat. 1965 ;28; 378-81
13. Jassim M. Al-Janabi, Mossa M, Marbut, Basma S, Ahmed, Adnan H, Murbat& Shaker M. Al.et alJobori . Determination of calcium & magnesium in the serum of epileptic patients .Tikrit Medical Journal 2005 ; 11(2):41-43
14. Parihar P, Yadav P, Ranka R, .Kaushik G.G , et al.Study of serum prolactin levels and electrolyte panel in patients with new onset seizures.Ijar .2015; 6 (3 ) :781-786
15. Djokic G,, Djukic D, Djordjevic V, Zivkovic N, Curcic D, Rankovic A, Radmanovic Branimir2,3, Janjic Vladimir2,. Interictal Ionized Magnesium/ Total Serum Magnesium Ratio in Serbian Population with Drug Resistant Epilepsy-Whether is Severe Epilepsy in Fact Brain Injury? Neuropsychiatry (London) 2017; 7(5): 629–636
16. Uzma J, Mazhar B, Ali Zohair N, MuhammadI, Jamal J .et al .Serum calcium and magnesium abnormalities in patients with status epilepticus: a single centretertiary care experience. Pakistan journal of neurological science. 2015;10(3):22-26
17. Oladipo OO, Ajala MO, Okubadejo N, et al. Plasma magnesium in adult Nigerian patients with epilepsy. Niger Postgrad Med J.2003;19:234–237.

Dr Shiva Kumar Mohanta

ViMSAR, Burla