Title: Lipid Pattern of Chronic Kidney Disease Patients on Hemodialysis and on Conservative Management- A Comparative Study
Authors: Dr Raghu Rama Reddy .A, Dr Girija .S, Dr Ravi Kumar .P
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.220
Abstract
Introduction: Chronic renal failure (CRF) is an irreversible condition, which is indicated by significant reduction in glomerular filtration rate, or irreversible destruction of kidney tissue.1 CRF is characterized by a wide variety of biochemical disturbances and numerous clinical symptoms and signs. Plasma cholesterol levels are usually normal in ureamia but elevated after renal transplantation. In renal failure, these abnormalities of carbohydrate and lipid metabolism presumably contribute to increased risk of atherogenesis, which may be troublesome in patients receiving long-term dialysis.8,9.
Thus the present study was conducted to compare the lipid profile in chronic kidney disease patients on regular hemodialysis and on conservative management
Materials and Methodology: A Hospital based case control study was conducted in Sri Manakula Vinayagar Medical College and Hospital, kalitheerthalkuppam for a period of 6 months, from May/2017 to October/2017. Patients who were diagnosed with Chronic Kidney Disease and admitted into the medical wards were included in the study. Patients with already known diabetes mellitus, ischemic heart disease, patients who had undergone coronary artery bypass graft, on lipid lowering drugs and history of alcohol consumption and smoking were excluded, from the study. Fasting lipid profiles of patients of chronic kidney disease on conservative management (group-I) and on hemodialysis (group-II) were compared.
Results: A total of 80 patients participated in the study. The mean age of the CRF patients was 53.25± 11.04 years. The mean age in our study among the group I participants (40) was 54.41± 10.86 years and in group II (40) it was found to be 51.87 ± 11.23 years. This study showed that total cholesterol, triglycerides, HDL, LDL, VLDL were significantly lower in the CRF patients on regular hemodialysis (p<0.05). Total cholesterol, triglycerides and VLDL were significantly higher among female gender with p value <0.05
Conclusion: Chronic kidney disease, due to its alteration in carbohydrate and lipid metabolism can lead on to increased atherogenesis and contribute to mortality. This necessitates the periodic monitoring and maintenance of lipid profiles within recommended range in CKD patients not on hemodialysis also.
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