Title: Comparative study of olmesartan and losartan in patient with hypertension for reduction of diastolic blood pressure
Author: Dr Amit Kumar Jha
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.218
Abstract
Hypertension also known as high blood pressure is long term medical condition in which blood pressure in the arteries is persistently elevated. Antihypertensive drugs are used to reduce blood pressure. Angiotensin receptor blocker shows beneficiary effect to control target organ damage. Study was carried out for production of hypertension by psychogenic stress method. In present work done by me antihypertensive effect of olmesartan and losartan was compared with control and with each other. Student t-test was done to compare result. It was found that blood pressure varied significantly across the three groups (p= .000) Compared to control, blood pressure was less in both olmesartan and losartan.
(p= .000) Reduction of blood pressure with losartan was less in comparision to olmesartan at end. Olmesartan is more efficacious than losartan as far as blood pressure reduction is concerned.
Keyword: Losartan, Olmesartan, Antihypertensive effect.
References
- Ganong William F. Cardiovascular Homeostasis health and disease Review of medical physiology. Lange/Mc graw Hill 21st edition USA; 2003, 633-648.
- Kumar cotran Robbins, Hypertensive heart- disease. Basic pathology. Elsevier 6th edition 1997, 308-339
- Crawford Michael H. Systemic hypertension. Current diagnosis and treatment cardiology. Tata MC graw Hill. 3rd 2010. New Delhi 153-163.
- Uday Kumar Padmaja Renin Angiotensin system and other vasoactive peptides medical pharmacology CBS pubhishers and distributors Pvt Ltd. Revised 4th edition New Delhi; 2013 127-134
- Tripathi KD.Drugs affecting Renin Angiotensin system and plasma Essential of medical pharmacology. Jaypee 6th edition New Delhi; 2008,479-492
- Gupta Sk antihypertensive agents. Drug screening methods. The health science publisher. 3rd edition New Delhi 2016. 266-277
- Mahajan Bk. Significence of difference in mean. Methods in Biostatistics Jaypee 7th edition New Delhi ;2010 117-141.
- Opril Suzanne et.al. comparative efficacy of olmesartan, losartan, valsartan and irbesartan in the control of Essential hypertension. Journal of clinical hypertension volume, 3 Issue 5, 31 may 2007, 1524-6175p.