Background: Pelvic Inflammatory Disease (PID) is the infection of upper female genital tract and is one of the major causes of gynaecologic morbidity. Appropriate and prompt treatment can prevent the complications of PID. The objective of this study is to evaluate the efficacy and safety of injection placentrex as compared to conventional therapy in pelvic inflammatory disease.

Methods: This is a randomized prospective study conducted on 90 patients with diagnosis of PID in a tertiary care centre over a period of one year. Patients were divided into three groups with 30 patients in each group. Group I, II and III were given injection placentrex, doxycycline and injection placentrex plus doxycycline respectively. Treatment was given treatment for 14 days. Final evaluation was done at the end of 2 weeks according to Clinical Global Impression (CGI) scale.

Results: Final assessment of efficacy of three groups was done according to Clinical Global Impression (CGI) scale. Excellent response was seen in 19(67.85%) cases in group I, 14(50%) cases in group II and 25(86.20%) cases in group III. Good response was seen in 5(17.85%) cases in group I, 2(7.14%) cases in group II and 2 (6.89%) cases in group III. Poor response was seen in 4 (14.28%) cases in group I, 12 (42.85%) cases in group II and 2(6.89%) cases in group III. The difference was statistically significant between group 1 versus 2 (p-0.049) and highly significant between group 2 versus 3 (p- 0.006).

Conclusion: Placentrex injection given from day one of diagnosis of PID is a better option for treating PID and in preventing complications of PID as compared to conventional antibiotics.

Keywords: PID, CGI scale, Placentrex .

1. Wiesenfeld HC, Sweet RL, Ness RB, Krohn MA, Amortegui AJ, Hillier SL. Comparison of acute and subclinical pelvic inflammatory disease. Sex Transm Dis. 2005;32(7):400–405. [PubMed]
2. Wiesenfeld HC, Hillier SL, Meyn LA, Amortegui AJ, Sweet RL. Subclinical pelvic inflammatory disease and infertility. Obstet Gynecol. 2012;120(1):37–43. [PubMed]
3. Bohm MK, Newman L, Satterwhite CL, Tao G, Weinstock HS. Pelvic inflammatory disease among privately insured women, united states, 2001–2005. Sex Transm Dis. 2010;37(3):131–6. [PubMed]
4. Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. [PubMed]
5. Pelvic Inflammatory Disease (PID) Atlanta, GA: Department of Health and Human Services; 2015.
6.  Sexually Transmitted Disease Surveillance, 2013. Atlanta, GA: Department of Health and Human Services; 2014.
7. Trent M, Bass D, Ness RB, Haggerty C. Recurrent PID, subsequent STI, and reproductive health outcomes: findings from the PID evaluation and clinical health (PEACH) study. Sex Transm Dis. 2011;38(9):879–881. [PMC free article][PubMed]
8. Bianchini P, Tellini N, Morani AM, Follono MG. Pharmacological Data on Polydeoxiribonucleotide of Human Placenta. Int.J.Tiss.Reac.1981;III,151-154.
9. Chakraborty PD, Bhattacharyya D. In vitro growth inhibition of microbes by human placental extract. Curr. Sc.2005; 88: 782-786.
10. Chakraborty PD, Bhattacharyya D. Isolation of fibrinectin Type III like peptide from human placental extract used as wound healer.J.Chromatogr.B 2005;818: 67-73.
11. Chakraborty PD, De D, Bandyopadhyay S, Bhattacharyya D. Human aqueous placental extract as a wound healer.J.Wound Care 2009;18:462-467.
12. Gupta R, Chattopadhyay D. Glutamate is the chemotaxis-inducing factor in placental extracts Amino Acids. 2010;39:615-618.
13. Prameela, Kavya D Sharma. Clinical efficacy of Placentrex Injection in pelvic inflammatory disease. Jr. of Obs & Gynae Research 2016; 3(1):65-67.
14. Dahiya P, Paul A. A randomized study to evaluate the efficacy and safety of placentrex injection in patients suffering from pelvic inflammatory disease. JIMA Vol. 111: 2013: 352-353.
15. Agarwal N, Kulshrestha V, Kriplani A. Clinical efficacy of placentrex injection in pelvic inflammatory disease. J Indian Med Assoc. 2010; 108: 117-118.
16. Garg R, Zahra F, Chandra JA, Vatsal P. A comparative study of injection Placentrex and conventional therapy in treatment of pelvic inflammatory diseases. J. Indian Med Assoc 2008: 106:463&467.

Dr Amarjeet Kaur

Senior Resident, Department of Obstetrics and Gynaecology, Govt. Medical College, Amritsar, 143001, India