Title: Amlodipine Induced Gingival Overgrowth and its Nonsurgical Management– A Case Report
Authors: Dr Suchetha Aghanashini, Dr Suma Prashanth, Dr Apoorva. S.M, Dr Darshan. B.M, Dr Sapna.N, Dr Divya Bhat
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.79
Abstract
Gingival enlargement or overgrowth is a well-known adverse effect associated with three major groups of drugs i.e., anticonvulsants, calcium channel blockers, and immunosuppressants. Among calcium channel blockers, nifedipine is the commonest cause for drug induced gingival overgrowth with the incidence of 10% whereas case report of gingival enlargement due to amlodipine are very less compared to nifedipine. Hence, we hereby report a case of amlodipine induced gingival overgrowth which intends to highlight the efficacy of conservative management with scaling, root planing and drug substitution.
Keywords: gingival overgrowth, amlodipine, scaling and root planing, drug substitution.
References
- Agrawal AA. Gingival enlargements: Differential diagnosis and review of literature. World Journal of Clinical Cases: WJCC. 2015 Sep 16;3(9):779.
- Bharti V, Bansal C. Drug-induced gingival overgrowth: the nemesis of gingiva unravelled. Journal of Indian Society of Periodontology. 2013 Mar;17(2):182.
- Livada R, Shiloah J. Calcium channel blocker-induced gingival enlargement. Journal of human hypertension. 2014 Jan;28(1):10.
- Thompson AL, Herman WW, Konzelman J, Collins MA. Treating patients with drug-induced gingival overgrowth. American Dental Hygienists' Association. 2004 Oct 1;78(4):12
- Hassan F, Tawfig N, Gobara B. Gingival overgrowth in subjects under immunosuppressive regimens based on tacrolimus or combination of tacrolimus and amlodipine. Dentistry. 2015;5(9):1-4.
- Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. The Lancet Neurology. 2003 Aug 1;2(8):473-81.
- Seymour RA, Ellis JS, Thomason JM, Monkman S, Idle JR. Amlodipine‐induced gingival overgrowth. Journal of clinical periodontology. 1994 Apr;21(4):281-3.
- Madi M, Shetty SR, Babu SG, Achalli S. Amlodipine-induced gingival hyperplasia–a case report and review. The West Indian medical journal. 2015 Jun;64(3):279.
- Joshi S, Bansal S. A rare case report of amlodipine-induced gingival enlargement and review of its pathogenesis. Case reports in dentistry. 2013;2013.
- Srivastava AK, Kundu D, Bandyopadhyay P, Pal AK. Management of amlodipine-induced gingival enlargement: Series of three cases. Journal of Indian Society of Periodontology. 2010 Oct;14(4):279.
- Tejnani A, Mani A, Sodhi NK, Mehta A, Gourkhede S, Thorat V, Marawar P. Incidence of amlodipine-induced gingival overgrowth in the rural population of Loni. Journal of Indian Society of Periodontology. 2014 Mar;18(2):226.
- Greenstein G. Nonsurgical periodontal therapy in 2000: a literature review. The Journal of the American Dental Association. 2000 Nov 1;131(11):1580-92.
- Funde S, Baburaj MD, Pimpale SK. Comparison between laser, electrocautery and scalpel in the treatment of drug-induced gingival overgrowth-a case report. IJSS Case Reports and Reviews. 2015 Mar;1(10):27-30.
- Chang CC, Lin TM, Chan CP, Pan WL. Nonsurgical periodontal treatment and prosthetic rehabilitation of a renal transplant patient with gingival enlargement: a case report with 2-year follow-up. BMC oral health. 2018 Dec;18(1):140.