Title: Histopathological Evaluation of Collagen Profiles in Spongiotic Dermatitis
Authors: Anjali Patankar, Ramya Gandhi*, Erli Amel Ivan
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.51
Abstract
Context: Spongiotic Dermatitis is a common clinical condition also known as eczema, characterized by rashes and itching further may progress to scarring. The terms eczema and dermatitis are often used interchangeably to denote a polymorphic inflammatory reaction pattern involving the epidermis and dermis. Spongiosis refers to intraepidermal edema.
Aim: To assess the orientation of collagen in eczematous spongiotic dermatitis.
Material and Methods: The present study was done in the Department of Pathology, Sri Manakula Vinayagar Medical College, Pondicherry. Sixty diagnosed cases of spongiotic dermatitis diagnosed over a period of five years were taken in the study. Orientation of collagen was evaluated using Masson’s trichrome stain.
Results: Spongiotic dermatitis occurred in all age groups but commonly seen in middle age to elderly. Male to female ratio was 1:1.2 The most common symptom was itching (85%) followed by scaling(63.3%). Most common site was upper extremities (80%). subacute cases were predominantly seen (38.3%) followed by chronic cases (33.3%). The most common orientation of collagen seen was vertical (38.3%) which was seen in (50%) of chronic cases.
Conclusion: The study emphasizes the need of using masson trichrome on skin biopsy showing spongiotic dermatitis to assess the collagen orientation and to know its chronicity.
Keywords: Spongiotic dermatitis, collagen, masson’s trichrome.
References
- Phelps RG, Miller MK, Singh F. The varieties of eczema; clinico pathologic correlation. Clin Dermatol 2003 Mar-Apr;21(2):95-100.
- Hanifin J, Reed M. A population-based survey of eczema prevalence in the United States. Dermatitis 2007;18(2):82-91.
- Beasley R. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The Lancet 1998;351(9111):1225-1232.
- Trautmann A, Altznauer F, Akdis M, Simon HU, Disch R, Brφcker EB et al. The differential fate of cadherins during T-cell-induced keratinocyte apoptosis leads to spongiosis in eczematous dermatitis. J Invest Dermatol 2001 Oct;117(4):927-934.
- Houck G, Saeed S, Stevens GL, Morgan MB. Eczema and the spongiotic dermatoses: A histologic and pathogenic update. Semin Cutan Med Surgery 2004;23(1):39-45.
- Hesari KK, Naraghi SZ, Ghanadan A, Nikoo A, Sabaghi M. Palmoplantar Psoriasis versus Eczema: Major Histopathologic Clues for Diagnosis. Iran J Pathol 2014;9(4):251–256.
- Raghu MT, Aravind K, Parvathi CN. A study of clinical types of contact allergic dermatitis of hands and its association with allergens. International Journal of Applied Research 2015;1(9):643-650.
- Gupta K. Deciphering spongiotic dermatitides. Indian J Dermatol Venereol Leprol 2008;74(5):523-526.
- Billings SD, Cotton J. Inflammatory dermatopathology. A pathologist’s survival guide. New York: Springer; 2011. p.5-16.
- Elder ED. Lever’s histopathology of the skin. In: Velazquez EF, Murphy GF, editors. Histology of skin. 10th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Williams; 2009. p. 29-66.