Title: Vitamin D Status in treatment naive HIV seropositive patients and its correlation with CD4 cells count
Authors: Dr Benrithung R Ngullie, Dr Rahul Kumar, Dr Rajesh Manocha, Dr VPS Punia, Dr Prabal Rajvanshi, Dr Sunil Ranga
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.18
Abstract
Introduction: Human Immunodeficiency Virus (HIV) infection is characterized by a progressive deterioration in immune function. Abnormalities in vitamin D status and metabolism might be an important concern in HIV patients. CD4 counts are the principal surrogate marker in assessing the degree of immune deficiency in HIV infected persons.
Objective: This study was performed to evaluate and compare vitamin D levels in treatment naïve HIV seropositive patients and its relationship to CD4 cells count.
Material and Methods: 50 cases and 50 controls of both sexes between the age of 18-70 years attending OPD of ART clinic and Department of Medicine were recruited and serum Vitamin D level and CD4 cell count were measured between January 2013 to December 2015.
Results: The mean and standard deviation values in the cases for Vitamin D were 10.9188 and 5.46304 respectively and for CD4 counts, mean and standard deviation were 294.8400 and 152.07790. The mean and standard deviation values in the controls for Vitamin D were 16.7388and 16.16334 respectively and for CD4 counts, mean and standard deviation were 1052.0400and 273.76237.
Conclusion: Vitamin D had a statistically significant positive correlation with CD4 count in cases but had a negative correlation with CD4 count in controls. All patients with HIV had Hypovitaminosis D. Vitamin D levels were found to be lower in older age groups and directly proportional to duration of sun exposure.
Keywords: Vitamin D, CD4 count, HIV.
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