Aim: Cancer cervix is the common malignancy among women globally. The Female population in developing countries is affected inspite of the Screening methods. The patients present in Locally advanced Stage due to Ignorance and Lack of awareness in wide geographic incidence spanning various continents. The aim of the Study is to assess the response with an aggressive treatment with Hyperfractionated Radio therapy and Concurrent cisplatin based chemotherapy in locally advanced Cancer cervix patients.

Patients and Methods: Most Patients belong to the Poor Socio Economic Stratum. Age group 30-60 Years with stage II B and Stage III B. Hyperfractionated Radio therapy 1.2 Gy bid (at 6 hours Interval) for 24 days upto 57.6Gy for 5days a week was given along with Concurrent Chemotherapy with cisplatin and was followed by HDR Brachytherapy 8 Gy in 2#- 1 week apart. The response was assessed after 6 weeks of Completion of treatment

Results: Total no of cases studied were -24 II B cases -14 and IIIB cases – 10. The Overall complete response – 92% and Partial response – 8%.

Conclusion: Invasive Cervical cancer is a Common cause of death in India. In view of the maximal therapy minimal time conceptual model concurrent Chemoradition appears to be ideal treatment to achieve maximal benefit the regimen uses gives better response in advanced stage, younger age group and lower Hemoglobin states at Presentation.

Keywords: Hyperfractionated Radiotherapy, Concurrent chemotherapy, brachytherapy, cancer cervix, cistplatin

1. Blake et al - Combined radiotherapy  and  chemotherapy  for advanced carcinoma   of the cervix. Clinical radiology 37(5):465- 469 Sep 1986.
2. Potish et al - Effect of Cisplatin on tolerance to radiation therapy in advanced  cervical    American  journal  of  clinical radiology. Vol 9:387-391, 1986.
3. Twiggs et al - Concurrent weekly Cisplatin and radiotherapy in advanced cervical Cancer. Gynecol oncology 24: 143-148, 1986. 61:416-422,
4. Fields et al - Mature results of a phase- II study on concomitant Cisplatin& pelvic  radiotherapy  in  locally  advanced  cervical cancer. Gynec oncology 1996.
5. Runowicz et al - Concurrent Cisplatin and radiotherapy in locally advanced cancer cervix. Gynec oncology -34:395-401, 1989
6. Souhami et al - Weekly Cisplatin and external beam radiation and HDR brachytherapy in locally advanced cancer cervix. Int J RadiatOncolBiol Phys.
7. Whitney et al-GOG 85 report. Journal of clinical oncology .Vol- 17:13391345,   
8. G. Rose et al - GOG 120 report. NEJM 340(15)1144-1153, April 1999.
9. Henry .M. Keys et a1 - GOG 123 report. NEJM 340( 15) 1154- 1161, April
10. Morris et a1 RTOG- 90-01 report. NEJM 340(15)1137- 1143, April 1999.
11. Peters et a1 SWOG-87-97 report- Gynec oncology 72: 443-450, 1999.
12. Ritsukokomaki M.D, Thomas F.Pajak, Victor A Marcial et. al Twice daily fractionation of external irradiation with brachytherapy in Bulky carcinoma of cervix RTOG 88-05 Cancer 1994 : 73 : 2619- 25.
13. Alison R Calkins.M.D et.al Hyperfractionated Radiation Therapy plus chemotherapy  in  locally  advanced  cervical  cancer Gynecologic oncology 5:3:349-355 1999.
14. W. Gregsby .J.D.LU: David Mutch ; Robert Y Kim patricia J Eifel.et.al Twice  daily  fractionation  of  external  irradiation  with brachytherapy and chemotherapy in carcinoma of cervix with positive para – aortic lymph nodes Gynecology cancer working group- Int Jou. Rad Oncology, Biology and physics-51(3) 58-59 , 2001.
15. Baskaran et.al Toxicities and tolerance of the Cancer Cervix patients Asian journal of Pharmaceutical and Clinical Research.Vol.4 Issue 1, 2011.

B.Antoinette Mary Nithiya. M.D., RT

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.