Title: Prevalence of androgen receptor positivity in triple negative breast cancers: clinico-pathological significance
Authors: Debahuti Mohapatra, Debasmita Das, Pranita Mohanty, Rajashree Tripathy
DOI: https://dx.doi.org/10.18535/jmscr/v7i1.142
Abstract
A unique subgroup of breast cancer, the Triple negative breast carcinoma (TNBC) is on rising trend. TNBC occurrence is around 15%-20% of all breast cancers. They are defined by absence of target therapy and prognostically worse as far as size, morphology, grading and staging are concerned. Thus, recent advent of androgen receptor (AR) sensitive target in some of the TNBC, which though are prognostically bad but has initiated target therapy successfully but still is under study. It is a sign of optimism for the oncologist for the treatment of incurable types of TNBCs. A study was done at IMS and SUM hospital, Bhubaneswar on 110 cases of breast carcinoma, among which 24 cases were TNBC. These included high grade infiltrating duct carcinoma (IDC-NST), metaplastic carcinomas, medullary carcinomas, neuro-endocrine carcinoma, apocrine carcinoma and acinic cell carcinoma. The tumors were designated as triple negative based on ER, PR, HER 2/neu staining. The proliferative index (Ki-67) and as well as AR staining were additional done, which showed 16.66% cases of AR positivity and most of which showed high proliferative index more than 21%.
Keywords: TNBC, Androgen receptor, Breast carcinoma.
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