Legg-calve Perthes Disease was an idiopathic osteonecrosis of developing femoral head complicated by pain and disability of hip joint. This study evaluated the changes in thrombotic protein in patients with LCPD. This study includes 10 Perthes disease were diagnosed based on symptoms, radiographic and clinical evaluation. These were compared with 10 controls of same age and sex. The mean age of effected population was 7.84±2.97 year. The male versus female population ratio was 2.33. In these 6 patients were belongs to Herring classification as C and 7 patients belongs to Catterall grade IV. In our study there is a highly significant difference in the values of FVIII between patients and controls. Effected boys significantly differ than girls. Low antithrombin levels would enhance thrombosis which was noted significantly. There were no significant differences in the values for protein C between patients and controls in our study. Protein S values and fibrinogen levels were also normal in our patients. The tests for sickle cell, Paroxysmal nocturnal haemoglobinuria were negative in both the patients and controls.

Keywords- Legg-calve Perthes Disease, thrombophilia, herring classification, Catterall grade.

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Dr Raghavendra Chidrawar

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