Title: Comparative evaluation of 25-Hydroxy vitamin D levels among women with polycystic ovarian syndrome and normal women of reproductive age group attending a tertiary care hospital
Authors: Dr Rukhsana Sami, Dr Sheikh Mohd Saleem, Dr Qazi Haroon
DOI: https://dx.doi.org/10.18535/jmscr/v7i1.107
Abstract
Background: Polycystic Ovary Syndrome (PCOS) has been termed as the most common endocrine entity encountered by the women of the reproductive age group. The aim of the study was to find the comparison between Vitamin D levels among Normal women and Women with PCOS in the reproductive age group at one of the largest maternity hospitals of Kashmir Valley.
Methods: The study was a cross-sectional study which was carried out at one of the largest maternity tertiary care hospitals of Kashmir Valley. Women in the reproductive age group, women diagnosed with PCOS using clinical or Ultrasound criteria. For comparison, women who attended the outpatient department for any cause other than PCOS were included in the study.
Results: The mean age of the patients was 28 ± 8 years in PCOS women and 27 ± 6 years among normal women without PCOS. Majority 99 (66%) of the patients without PCOS were having serum fasting insulin levels within normal range while 123 (82%) among PCOS were having increased levels of serum fasting insulin levels. Moreover, 148 (99%) of PCOS patients fall under any one of the categories of Vitamin D deficiency while the reverse was true for women without PCOS.
Conclusion: Fasting serum Insulin levels and Serum 25(OH) Vitamin-D levels were significantly lower in PCOS women than the normal women in the reproductive age group.
Keywords: PCOS, Ovarian Disease, 25(OH) D Levels, Insulin Levels.
References
- Li H, Brereton R, Anderson R et (2011): Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism,60:1475-1481.
- Haoula Z, Salman M and Atiomo W (2012): Evaluating the association between endometrial cancer and polycystic ovary Hum. Reprod., 27:1327-1331.
- Studzinski G, McLane J and Uskokovic M (1993):Signaling pathways for vitamin D-induced differentiation: implications for therapy of proliferative and neoplastic Crit. Rev. Eukaryot. Gene Expr.,3:279-312.
- Irani M and Merhi Z (2014): Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil. Steril., 102: 460-469.
- N. Kalro, T. L. Loucks, and S. L. Berga, Neuromodulation in polycystic ovary syndrome, Infertility and Reproductive Medicine Clinics of North America, 14, no. 4,529–555, (2003).
- Speroff and MA. Fritz, Chronic Anovulation and The Polycystic Ovary Syndrome,in Clinical Gynecologic, Endocrinology and Infertility, 495–533, 2011, 8th ed.
- Wehr, S. Pilz, N. Schweighofer, A. Giuliani, D. Kopera, T. R. Pieber, and B.Obermayer-Pietsch, Association of hypovitaminosis D with metabolic disturbancesin polycystic ovary syndrome, European Journal of Endocrinology, 161, no. 4, 575–582,(2009).
- Wehr, O. Trummer, A. Giuliani, H.-J. Gruber, T. R. Pieber, and B. Obermayer-Pietsch,Vitamin D-associated polymorphisms are related to insulin resistance and vitaminD deficiency in polycystic ovary syndrome, European Journal of Endocrinology, 164,no. 5, 741–749, (2011).
- F. Holick, Medical progress: Vitamin D deficiency, New England Journal ofMedicine, 357, no. 3, 266–281, (2007).
- Lips P (2010): Worldwide status of vitamin D nutrition. J .Steroid .Biochem Mol. Biol.,121:297-300.
- Holick M (2007): Medical progress: vitamin D deficiency. New England Journal of Medicine,3: 266–281.
- Franks S (1995): polycystic ovary pathogenesis of PCOS. N. Engl. J. Med., 333:853-861.
- Sheikh Mohd Saleem. Modified Kappuswamy scale updated for year 2018. Indian J Res. 2018;7(3):6–7.
- Ngo D, Chan W, Rajendran S et Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide and vitamin D. Nitric Oxide,2011. 25: 326–330.
- Mahmoudi T, Gourabi H, Ashrafi M et Calciotropic hormones, insulin resistance and the polycystic ovary syndrome. Fertility and Sterility, 2010.93: 1208–1214.
- Moini A, Shirzad N, Ahmadzadeh M et Comparison of 25-hydroxyvitamin D and calcium levels between polycystic ovarian syndrome and normal women. Int. J .Fertil. Steril.2015, 9: 1-8.
- Figurová J, Dravecká I, Javorský M et Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities. Wien. Klin. Wochenschr.2016,10: 1-8.
- Elida S, Binarwan H, Muhammad F et Vitamin D levels in women with polycystic ovary syndrome. ASPIRE Conference Proceedings, The 6thCongress of the Asia Pacific Initiative on Repro-duction. KNE Medicine, 2016.125:88-95
- Wehr E, Pilz S, Schweighofer N et Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome Eur. J Endocrinol.2009 ,161:575-82.