Title: Transfusion transmissible infections in blood donors in central India at Indore: A 7 year study
Authors: Dr Chandrashekhar Chhatrasal, Dr Priya Jain, Dr Ashok Yadav, Dr Pankaj Shinde
DOI: https://dx.doi.org/10.18535/jmscr/v7i1.102
Abstract
Introduction
Blood transfusions are inevitable element of modern medicine. Simultaneously, it is not a risk free procedure. It is associated with transfusion transmissible infections (TTIs) and transfusion reactions. Approximately, 1% of transfusions are associated with adverse events.[1] TTIs include human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), Syphilis and Malaria. Outcome of TTIs ranges from subclinical to life-threatening manifestations of diseases. Various testings are helpful to reduce TTIs, but not up to 100%. There is always chance of false-negative due to detection limitation of kits used and “window period” of diseases. Minimizing its use and taking donation from low risk population for TTIs are some of the modalities used for reduction for adverse events associated with blood transfusions.
Aims and Objectives
The aim of this study was to determine the prevalence of TTIs in blood donors, voluntary as well as replacement and to evaluate trends in TTIs in blood donors.
References
- Widmann FK, editor. Technical Manual, 9th ed. Arlington USA: American Association of Blood Banks; 1985. p. 325-44.
- Seroprevalence and Trends in Transfusion Transmitted Infections Among Blood Donors in a University Hospital Blood Bank: A 5 Year Study: P. Pallavi , C. K. Ganesh , K. Jayashree , G. V. Manjunath: Indian J Hematol Blood Transfus (Jan-Mar 2011) 27(1):1–6
- Gupta N, Kumar V, Kaur A (2004) Seroprevalence of HIV, HBV,HCV and syphilis in voluntary blood donors. Indian J Med Sci 58:255–257
- Pahuja S, Sharma M, Baitha B, Jain M (2007) Prevalence and trends of markers of hepatitis C virus, hepatitis B virus and human immunodeficiency virus in Delhi blood donors. A hospital based study. Jpn J Inf Dis 60:389–391
- Chandra T, Kumar A, Gupta A (2009) Prevalence of transfusion transmitted infections in blood donors: an Indian experience. Trop Doct 39:152–154 Indian J Hematol Blood Transfus (Jan-Mar 2011) 27(1):1–6 5.
- Arora D, Arora B, Khetarpal A (2010) Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana. Indian J Pathol Microbiol 53:308–309.
- Srikrishna A, Sitalakshmi S, Damodar P (1999) How safe are our Garg S, Mathur DR, Gard DK (2001) Comparison of seropositivity of HIV, HBV, HCV and syphilis in replacement and voluntary 44:409–412.