Objectives: We conducted this prospective case-control study in rural population based medical institute of central India. The aim of the study was to assess and analyze the coagulation profile (PT, aPTT, fibrinogen and fibrin degradation product [FDP] levels) and platelet counts in 3^rd trimester normotensive, pre-eclamptic and eclamptic pregnant women.

Methods: In all subjects (cases and controls) 2 ml of blood sample was collected in EDTA and tri-sodium citrate bulbs for platelet counts and coagulation profile respectively.

Results: The mean PT and aPTT were significantly high in cases and mean fibrinogen level was significantly low in cases as compared to controls. FDP was significantly increased in cases as compared to non-detectable level in the controls. Thrombocytopenia was observed in 45% of cases. No any correlation between level of platelet count and abnormal coagulation test results (PT, aPTT, fibrinogen and FDP) were found.

Conclusion: We found in our study that platelet count and above coagulation tests should be performed in cases of pre eclampsia and eclampsia to identify severity of disease and to prevent development of complications.

Keywords: pre eclampsia, eclampsia, platelet count, coagulation tests.

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Vishal Agrawal

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