Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that may involve many different organs and display a variable clinical course. From a pathogenetic point of view, the production of several autoantibodies characterizes the disease. The diagnosis of SLE is based on characteristic clinical findings of the skin, joints, kidneys, and the central nervous system, as well as on serological parameters such as antinuclear antibodies (ANA), in particular, antibodies to dsDNA.^[1] Here we present the case of a 30-year-old female patient, known case of hypothyroidism, who presented with polyserositis and renal involvement and upon investigations was diagnosed to be a case of Anti-ds DNA negative lupus nephritis.

1. Bertsias G, Cervera R, Boumpas D. Systemic lupus erythematosus: pathogenesis and clinical features. In: Bijlsma J, editor. EULAR textbook on rheumatic diseases. London: BMJ Group; 2012. pp. 476–505.
2. C. Tsokos, “Systemic lupus erythematosus,” The New England Journal of Medicine, vol. 365, no. 22, pp. 2110–2121, 2011.
3. Conti, F. Ceccarelli, C. Perricone et al., “Flare, persistently active disease, and serologically active clinically quiescent disease in systemic lupus erythematosus: a 2-year follow-up study,” PLoS ONE, vol. 7, no. 9, Article ID e45934, 2012.
4. A. Isenberg, J. J. Manson, M. R. Ehrenstein, and A. Rahman, “Fifty years of anti-ds DNA antibodies: are we approaching journey's end?” Rheumatology, vol. 46, no. 7, pp. 1052–1056, 2007.
5. Cozzani, M. Drosera, G. Gasparini, and A. Parodi, “Serology of lupus erythematosus: correlation between immunopathological features and clinical aspects,” Autoimmune Diseases, vol. 2014, Article ID 321359, 13 pages, 2014.
6. M. H. Foster, B. Cizman, and M. P. Madaio, “Nephritogenic autoantibodies in systemic lupus erythematosus: immunochemical properties, mechanisms of immune deposition, and genetic origins,” Laboratory Investigation, vol. 69, no. 5, pp. 494–507, 1993.

Viral Sangwan

PT BDS PGIMS Rohtak, India