Introduction: Hypogonadism is common in diabetes and prediabetes both. Metformin ,insulin sensitiser, is approved therapy for prediabetes

Aim of the study: to assess whether metformin has any effect on serum testosterone level or not in males with prediabetes

Materials and Methods: 48 males with prediabetes participated in the study .They were divided in two groups -Group A with baseline serum testosterone level more than 300 ng/dl and Group B with baseline serum testosterone level less than 300 ng/dl. Their testosterone levels were re-evaluated after 3 months of metformin therapy

Result: Prediabetes men in hypogonadal group showed significant improvement in serum testosterone level. Both groups participants  had improvement in erectile dysfunction

Conclusion: metformin therapy in prediabetes male also helps in improvement of testosterone level

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Dr Animesh Maiti

Associate Professor Dept of Endocrinology and Metabolism Medical College, Kolkata