Undifferentiated pleomorphic sarcoma (Malignant fibrous histiocytoma) is a sarcoma that arise from bone or soft tissue. it is the most common type of sarcoma of extremity while MFH of bone is very rare. It occurs most frequently in age group of 45-55 yrs of age. The origin of tumor is not known, and one of the major predisposing factors is radiation. Other Causes include paget’s disease, non-ossifying fibroma and fibrous dysplasia. Post radiation sarcoma accounts for 0.5% to 5.5%.Osteosarcoma, malignant fibrous histiocytoma and fibrosarcoma are the most common .Because adjuvant RT after breast conserving surgery plays a significant role in treatment of early – stage breast cancer, sarcoma of the breast, chest wall, sternum, axilla or supraclavicular region have been reported as a complication of treatment  for breast cancer. We report here a rare case of undifferentiated pleomorphic sarcoma of chest wall in a 51yr old woman who had underwent 6 cycles of chemotherapy and  radiation  following modified radical mastectomy for carcinoma breast

Keywords: Undifferentiated pleomorphic sarcoma, Malignant fibrous histiocytoma (MFH), Radiation therapy (RT).

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Dr Karthi.P. Kumar

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