Background: Homeless is worldwide problem, developed and under-developed countries are suffering from, rises leading to  health problem, drugs and alcohol related , lack to engage and to medical care, so they develop chronic disorders and that rises morbidity and mortality..

Objective: The aim of this study to evaluate the levels of urea, creatinine, calcium, magnesium and urea/creatinine ratio in homeless individual ,and the effect of the drugs abuse on measured parameters..

Materials and Methods: 50 drugs abuse homeless members were volunteer to assess urea, creatinine, urea /creatinine ratio, calcium and magnesium .In addition 50 healthy controls were involved. Parameters were measured by means of semi – automated chemical analyzer BTS 350, using Biosystem reagents, data obtained analyzed via statistical pakage of social version 22.

Results: The level of serum creatinine and urea was significantly increased in drugs abuse homeless group when compared with reference group (0.56±0.23 mg/dl versus 0.93±0.19) (P 0.5). Also the urea creatinine ratio was significantly higher in drugs abuse homeless group when compare with health control (49.9±29.15 mg/dl versus 24.56±8.77) (P = 0.000).The study illustrated significant decrease in the level of both calcium and magnesium in drugs abuse homeless group when compared with reference group (8.62±0.53mg/dl versus 9.53±0.67.mg/dl p= 0.000, 2.196±0.37mg/dl versus 1.97±0.40 mg/dl p= 0.005 respectively). Across the gender the study deduced significant difference in urea and creatinine levels (male 27.40 ±2.74 mg/dl female 21.11±2.49 mg/dl p =0.002, male 0.97±0.04 female 0.51±0.02mg/dl p= 0.027 respectively) where as there is insignificant difference in calcium and magnesium levels (p ≥ 0.05) in the drugs abuse homless group. Furthermore  the levels of creatine and urea were significantly positively correlated with duration of drugs abuse homless (p<0.05), where as calcium and magnesium levels were significantly inversely correlated with  duration of drugs abuse homless in the study group(p< 0.05). Across the gender urea and creatinine were significantly differ (p < 0.05) where as there is insignificant difference in calcium and magnesium levels (p > 0.05) in the drugs abuse homless group.

Conclusion: Substances abuse by homeless significantly impairs the renal function and decreased calcium and magnesium levels, so they should be considered as risk factors for kidney injury and osteoporosis among homeless.

Keywords: Drugs Abuse homeless, Urea, Creatinine, calcium. Magnesium. Urea Creatinine Rati.

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Abdelmula Mohammed Abdalla

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences

Alneelien University – Khartoum, Sudan