Objective: To study the associated between the serum level of vitamin D and calcium among women with early pregnancy loss.

Study Design: This is a prospective study which is conducted in Basrah Maternity and Child Hospital. The study involved 280 women who were divided into 4 groups: 70 pregnant women with healthy pregnancy in the first group, 70 pregnant women with early unhealthy pregnancy in the second group, further, 70 with non-pregnant women with no pregnancy loss in the third group and then the fourth group included  70 women with non-pregnant women with history of pregnancy loss. Plasma was collected from 280 women and serum 25(OH)D and calcium level were estimated and compared between the groups.

Results: Serum 25(OH)D levels for the 4 groups were measured as (45.73±2 ng/ml) in group 1, (20.2±1.4 ng/ml) in group 2, (37.6±2.1 ng/ml) in group 3 and (11.5 ± 3.1 ng/ml) in group 4. There was a clear correlation between low 25(OH)D levels as well as low calcium level and early pregnancy loss.

Conclusion: Vitamin D has a significant role during pregnancy from early implantation and decidualization phase till late pregnancy. Vitamin D deficiency related to poor obstetric outcome. Many studies proved that Vitamin D supplement improved outcome. So, routine screening and supplementation of vitamin D in early pregnancy especially during first trimester are recommended.

Keywords: Calcium, Miscarriage, Pregnancy, Vitamin D.

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Prof. Maysoon Sharief

Central Post Office-42001, P. O. Box 1565 Ashar, Basrah, Iraq

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