Title: Attenuation of Pressor Response during Laryngoscopy and Tracheal Intubation by Placebo, Lignocaine and Esmolol – A Comparative Clinical Study
Authors: Dr Suma R, Dr Linette J Morris, Dr Ceena Panicker
DOI: https://dx.doi.org/10.18535/jmscr/v6i11.23
Abstract
Background and Aims: Laryngoscopy and tracheal intubation causes sympathoadrenal stimulation and cause transient rise in pulse rate and blood pressure. We evaluated the efficacy of Esmolol and Lignocaine in attenuating the pressor response during laryngoscopy and inutbation as compared to placebo.
Methods: 60 patients of ASA I & II between the age group of 20-60 were randomized to receive either Esmolol 1.5 mg/Kg, Lignocaine 1.5mg/Kg or 5ml normal saline just prior to induction of anaesthesia. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded before induction (baseline) and at regular intervals of 1, 3, 5, 7 and 10 minutes after induction. Statistical analysis was done using Student’s t test and chi-square test and p values obtained.
Results: There is an increase in HR, SBP and DBP in the control group which is maximum at 3 mins after induction (i.e. during laryngoscopy and tracheal intubation). Whereas in the study groups there was no significant variation in these parameters from baseline which is found to be more effective with Esmolol (p-value < 0.001) than Lignocaine.
Conclusion: Esmolol 1.5mg/Kg was found to be more effective in attenuating pressor response to laryngoscopy and intubation when compared to Lignocaine.
Keywords: Esmolol, lignocaine, attenuation of pressor response, laryngoscopy, tracheal intubation, pressor response, blood pressure, heart rate.
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