Title: Study of Renal Parameters in Preeclampsia
Authors: Dr Asha.N.S., Dr Anju Varghese
DOI: https://dx.doi.org/10.18535/jmscr/v6i10.227
Abstract
Preeclampsia is a pregnancy specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation. In this study the renal parameters of preeclamptic patients were compared with normal pregnant ladies. 50 preeclamptic patients and 50 normotensive pregnant women were selected for the study. Blood was collected and blood urea, serum creatinine and uric acid were estimated and compared. It is seen that there is a significant elevation in B.urea, S.creatinine and S.uric acid in preeclampsia.
Keywords: preeclampsia, urea, uric acid, creatinine, uteroplacental ischemia.
References
- Brown JC and Vaelle N. The maternal placental blood flow in normotensive women. J Obstet Gynecol Br Commonwealth1953; 60: 141.
- Berger M and Cavanaugh D. Toxemia of pregnancy and the hypertensive effect of acute experimental placental ischemia. Am J Obstet Gynecol 1963; 87: 293.
- World Health Organization Study Group. The hypertensive disorders of pregnancy. W.H.O Technical report series 758, Geneva: WHO 1987.
- Davey DA. Hypertensive disorders in pregnancy. In: Whitfield CR, ed. Dewhurst Obs Gynae for post graduates. Oxford: Blackwell Scientific, 1986, pp 200-241.
- Lyall F and Greer IA. Is preeclampsia a preventable disease? In: Bonner J, ed. Recent advances in obstetrics and gynecology, 18. UK: Churchill Livingston, 1994, pp 3-21.
- Uzun, H., Benian, A., Topcuoglu, MA., Aydin, S., Albayrak, M. Circulating Oxidized low-Density Lipoprotein and Paroxanase Activityin preeclampsia. Obstetrics And Gynaecology Investigation 60:195 200. (2005).
- Harold Varley, et al (1991) Principle of determination of blood urea by diacetyl monoxime method. Practical Clinical Biochemistry; 5: 459.
- Marsh WH, Fingerhut, Band Miller H. Determination of serum urea. Clin. Chem 1965; 11: 624.
- Oven J, Iggo B, Stewart CP. Principle of determination of serum creatinine. Biochem J 1954; 58: 426.
- Brod J and Sirota JH. Jaffe’s method of determination of serum creatinine. J. Clin. Invest. 1948; 27: 645.
- Thefeld W et al. Dtsch Med Wschr, 1973;98: 380.
- Fossatti P, et al. Clin Chem 1980; 26: 227.
- Hassan TJ, Sadaruddin A, Jafarey SN. Serum calcium, urea and uric acid levels in pre-eclampsia. J Pak Med Assoc. 1991, 41:183-185.
- Mohamed Abdulfatah Abdulmunem. “The Values of Plasma Uric acid, Urea, Creatinine and Electrolytes in Diagnosis of Preeclampsia.” Thesis. Sudan University of Sciences, 2005.
- Wakwe VC, Abudu OO. Estimation of plasma uric acid in pregnancy induced hypertension (PIH). Is the test still relevant? Afr J Med Med Sci. 1999, 28:155- 158.
- Waring WS. Antioxidants in prevention and treatment of cardiovascular disease. Proc R Coll Physicians Edinb 2001, 31: 288-292.