Background: Acute Coronary Syndrome is one of the commonly diagnosed life threatening condition as of now. Hence it is necessary to diagnose early and assess the severity of disease as soon as possible. This study is done to prove the correlation of cardiac marker NT-pro BNP in Acute Coronary Syndrome.

Aim: To estimate the serum level of N-terminal pro-Brain natriuretic peptide levels in Acute coronary syndrome and its relationship between STEMI, NSTEMI and Unstable angina patients. Also to find the association for levels of NT-pro-BNP in patients with acute coronary syndrome and ejection fraction.

Materials and Methods: 40 patients of age group between 30 to 60 of both sexes who got admitted within 12 hours after onset of symptoms and diagnosed as Acute Coronary Syndrome (STEMI, NSTEMI & Unstable Angina)  in Rajah Muthiah Medical College & Hospital at Chidambaram, Tamilnadu during the period of November 2016 to August 2018) without heart failure (≥ Killip class II were excluded) and chronic kidney disease were taken for the present study. The levels of NT-Pro BNP were measure in blood with Rapid NT-Pro BNP Assay kit.

Results: The mean age of the patient was 49-10+7.45 years & majority were males (around 60%). Among ACS NT-pro BNP was higher (>100) in most of the patients (85 %) patients in the study .Here in this study majority patients was STEMI (57.5%) followed by NSTEMI (25%) & Unstable Angina (7%). The majority of patients with low Ejection Fraction had greater NT pro BNP (N=4, 66.7%) and majority of normal Ejection Fraction (N=5, 62.5%) had lower NT pro BNP (<100) which was statistically significant.

Conclusion: NT-pro BNP is reliable biomarker in diagnosing not only STEMI & NSTEMI but also in unstable angina. NT-pro BNP is high in STEMI compared to NSTEMI & UA. Levels of NT-pro BNP is significantly had inverse proportion to Ejection Fraction. Low NT-proBNP levels at the time of admission rule out high-risk patients and patients with heart failure.

Keywords: Acute Coronary Syndromes, STEMI, NSTEMI, Unstable Angina, NT-pro BNP, cardiac markers.

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Prof Dr M. Senthilvelan

Professor & HOD, Department of General Medicine, Rajah Muthiah Medical College, Annamalai University, Chidambaram, Tamilnadu, India

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