Introduction: Hyperuricemia is a common finding in preeclamptic pregnancies evident from early pregnancy.

Objective: In this study our main goal is to evaluate the effect of maternal hyperuricemia and birth outcome in normotensive singleton pregnancy.

Method: This prospective study was conducted at the department of Obstetrics and Gynecology, Institute of Child and Mother Health, Dhaka from January 2016 to January 2017 where total 102 normotensive singleton pregnant women examined. Two patients were excluded from the study due to lack of data. Data were analyzed using SPSS -21 windows version statistical package. Categorical variables were presented by frequency and percentage, and continuous variable by mean (sd) in case of normally distributed data and median (min-Max) in case of asymmetric data.

Results: During the study SBP mean level was 35.66 higher than DBP and for pregnant women found that gestational age 38 weeks and over then the serum uric acid level was higher. Also, LBWB was 36.7% lower than hyperuricemia.

Conclusion: we can conclude that Hyperuricemia is a risk factor for adverse pregnancy outcome for normotensive mother and LBWB is a concern in this regard. More studies and examinations are needed to confirm these results, as genetic, socioeconomic and dietary factors play key roles in uric acid concentrations.

Keywords: Hyperuricemia, Normotensive, Low birth weight baby (LBWB).

1. Katz JL, Weiner H: Psychosomatic considerations in hyperuricemia and gout. Psychosom Med. 1972, 34: 165-182
2. Luo ZC, An N, Xu HR, Larante A, Audibert F, Fraser WD: The effects and mechanisms of primiparity on the risk of pre-eclampsia: a systematic review. Paediatr Perinat Epidemiol. 2007, 21 (Suppl 1): 36-45.
3. https://www.google.com/search?q=hyperuricemia&tbm=isch&tbs=rimg:CSGHmlGx3fwNIjh6f-lZ6rAylgfUmEamIYGpwlyHSLZXVXeBPIkZ9vmxfEV4iwvD7mMFoYv1DbkbV6_1ByhRgdawvyoSCXp_16VnqsDKWET9ufOJLaBvVKhIJB9SYRqYhgakRUt0wWqRX9yAqEgnCXIdItldVdxFrARCN8xJH9yoSCYE8iRn36-bFEQfvdovLytMcKhIJ8RXiLC8PuYwRDhN3oJC7UZIqEgkWhi_1UNuRtXhHvQ2bgIhkGbSoSCb8HKFGB1rC_1EQG7ia2zl4Hb&tbo=u&sa=X&ved=2ahUKEwiNmJGR8_rdAhVMuI8KHcHwAlUQ9C96BAgBEBg&biw=1366&bih=662&dpr=1#imgrc=vwcoUYHWsL-nPM:
4. Ahaneku JE, Adinma JI, Ahaneku GI, Nwosu BO, Nwofor PC, Okoli CC: Serum urea and uric acid concentration in pregnant women in sub-urban commercial community in Africa. Niger J Clin Pract2009;12:216–18.
5. Perlman JM, Risser R. Relationship of uric acid concentrations and severe intraventricular hemorrhage/leukomalacia in the premature infant. J Pediatr. 1998;132:436–439. doi: 10.1016/S0022-3476(98)70016-2.
6. Amini, Elaheh, Mahdi Sheikh, Sedigheh Hantoushzadeh, Mamak Shariat, Alireza Abdollahi, and Maryam Kashanian. "Maternal hyperuricemia in normotensive singleton pregnancy, a prenatal finding with continuous perinatal and postnatal effects, a prospective cohort study." BMC pregnancy and childbirth 14, no. 1 (2014): 104.
7. Hawkins TL, Roberts JM, Mangos GJ, Davis GK, Roberts LM, Brown MA: Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study. BJOG 2012;119:484–92.
8. Akahori Y, Masuyama H, Hiramatsu Y: The correlation of maternal uric acid concentration with small-for-gestational-age fetuses in normotensive pregnant women. Gynecol Obstet Invest 2012;73: 162–67.
9. Laughon SK, Catov J, Roberts JM. Uric acid concentrations are associated with insulin resistance and birth weight in normotensive pregnant women. Am J Obstet Gynecol. 2009;201(582):e1–e6.
10. Chang FM, Chow SN, Huang HC, Hsieh FJ, Chen HY, Lee TY, Ouyang PC, Chen YP. The placental transfer and concentration difference in maternal and neonatal serum uric acid at parturition: comparison of normal pregnancies and gestosis. Biol Res Pregnancy Perinatol. 1987; 8(1 1ST Half)):35–39.

Dr Tahmina Afreen Daise

Associate Professor, Department of Obstetrics and Gynaecology, Institute of Child and Mother Health (ICMH), Dhaka