Title: Assessment of QTc Dispersion in Psoriasis Patients: A Case Control Study
Authors: M.A.Arumugam, M. Vijaya Anand, Alamelu Alagappan
DOI: https://dx.doi.org/10.18535/jmscr/v6i10.66
Abstract
Background: Multiple studies demonstrated the association between psoriasis and cardiovascular diseases. QT dispersion (QTD) can be employed to evaluate the cardiac repolarization homogeneity and might be a risk for ventricular arrhythmias.
Objective: To evaluate the prevalence of QTD in psoriasis patients and compare with the control.
Methods: In this study 38 psoriasis patients and 38 healthy people were evaluated by physical examination, 12-lead ECG, Severity of the psoriasis was evaluated by psoriasis area and severity. Further anthropometric parameters like waist circumference were measured. Biochemical evaluation fasting blood glucose, lipid profile and kidney profile were estimated. index (PASI).
Results: In this mean PASI score was 9.91 ± 1.25. The psoriasis subjects displayed higher waist circumference as that of the control (p<0.05), Further, the HDL level was significantly decreased in psoriasis patients as that of the control subjects (p<0.05). Further, psoriasis patients displayed longer QTcD as that of the control, but the value was found to be non significant (74.23 ± 33.48 vs 70.78 ± 29.98).
Conclusion: Thus, based on the observation in the present study, QTcD were increased in psoriasis patients compared to normal subjects.
Keywords: Psoriasis, PASI, cardiovascular disease, QTc dispersion, Electro cardiogram.
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