Title: Dexmedetomidine and Clonidine as an Adjuvant to Ropivacaine for Epidural Anaesthesia
Authors: Gullapalli Hanumantharao, G. Bharathi, K. Nagarjuna Reddy
DOI: https://dx.doi.org/10.18535/jmscr/v6i10.32
Abstract
Regional Anaesthesia is an excellent choice which provides effective intra & post-operative analgesia with a single technique which is being possible due to the availability of long acting amide local anaesthetics like Ropivacaine and by the addition of adjuvants like clonidine and Dexmedetomidine. In our study we compared the effects of Clonidine (2mcg/kg) with Dexmedetomidine (1.5mcg/kg) as an adjunct to Epidural 0.75% Ropivacaine in lower abdominal and lower limb surgeries in adult patients. The mean time of onset of sensory blockade and mean time of onset of motor blockade in Dexmedetomidine group is significantly less than Clonidine group. The 2 segment regression time, The mean duration of sensory blockade and mean duration of motor blockade was significantly higher with Dexmedetomidine group than Clonidine group. The duration of analgesia was significantly prolonged and highest in the Dexmedetomidine group compared to Clonidine group. Both groups were similar in haemodynamic stability. We conclude that dexmedetomidine is a better adjuvant than clonidine in epidural anaesthesia as far as patient comfort, stable cardio-respiratory parameters, intra-operative and post-operative analgesia is concerned.
Keywords: Dexmedetomidine, Ropivacaine, Clonidine, Epidural, Regional Anaesthesia, Haemodynamics.
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