Introduction: Peptic ulcer disease (PUD) is very common problem encountered by physicians in day-to-day practice. Prevalence of this disease varies from country to country and Previous concept regarding PUD was that “no acid, no ulcer”. Now, it is certain that H. pylori is the main agent causing peptic ulcer.H. pylori is found in 95% of patients with duodenal ulcers and 70% of cases with gastric ulcers. H. pylori infection is chronic and once acquired remains life long, unless eradicated by antibiotics given for some other conditions.

Methods and Materials: This study was conducted on 100 acid PUD patients at Internal Medicine Department of Index Medical College Hospital and Research Centre, Indore from October 2017 to April 2018.Patients who were suffering from symptoms related to PUD who gave consent for upper gastrointestinal endoscopy, those patients were selected for this study and the H. pylori infection was detacted by rapid urease test (RUT) kit test.

Results: Among the 100 patients of PUD who were studied in this study, 75 patients had RUT positive result and 25 patients had RUT negative result. It was also observed that amongst the RUT positive patients, those who had strongly positive RUT status, they had more severe form of peptic ulcer disease, whereas weakly positive RUT patients had moderately severe form of the disease, and those who had negative RUT report, they had very minor form of the disease.

Conclusion: High prevalence of H. pylori infection is found in patients suffering from PUD in rural India hence its treatment can help in preventing significant morbidity as well as recurrence in these patients. Patients with various complaints, where UGI endoscopy is done, they should routinely have their H. pylori status checked, regardless of indication.

Keywords: Peptic ulcer disease, H. pylori, Upper gastrointestinal endoscopy, Rapid Urease Test.

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Dr Manuj Kumar Sarkar

Associate Professor, Department of Medicine, Amaltas Institute of Medical Sciences, Devas, MP, India

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