Aim: The aim of the study was to study the impact of disease duration on lipid profile in type 2 diabetes mellitus patients.

Methods: Total 30 diagnosed type 2 diabetic subjects were taken .The anthropometric parameters were measured by standard methods. The serum samples were used for serum glucose, total cholesterol, triglycerides, HDL- cholesterol was estimated by full automated chemistry analyzer (Siemens-Dimension-RxL Max). The plasma HbA1c estimated by Nyco card reader. VLDL and LDL were calculated by using Friedwald’s Formula.

Results: There was significantly positive correlation occurs between disease duration with total cholesterol, triglycerides and VLDL-cholesterol having r-value of 0.858, 0.727 and 0.723 respectively at p-value 0.01 levels. There was significantly positive correlation occurs between disease duration with LDL-cholesterol having r-value of 0.849 at p-value 0.05 levels but there was no significant correlation between disease duration and HDL-cholesterol in type 2 diabetes mellitus patients

Conclusion: There was more altered lipid metabolism as the duration of diseases increases, indicating that proper management must be taken to prevent the secondary complication which leads to cardiovascular diseases. As the age advances, the degree of dyslipidemia also increases in both genders

Keywords: lipid profile, type 2 diabetes mellitus, duration of disease, cholesterol.

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Ashish Kumar Sharma

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