Title: A Study on Seroconversion in HBeAg Antigen Positive Chronic Hepatitis B Patients with Tenofovir Therapy
Author: Pinaki Nath, Soumya Sarathi Mondal, Sanjay Kumar Mandal, Koelina Sil
DOI: https://dx.doi.org/10.18535/jmscr/v6i9.69
Abstract
Introduction: Chronic Hepatitis B remains most important risk factor for developing cirrhosis, hepatic decompensation and hepatocellular carcinoma. So treatment with tenofovir of HbeAg positive Chronic Hepatitis B and seroconversion is the major concern.
Aim: To see the HbeAg and HbsAg loss after receiving tenofovic therapy for 6 and 12 months.
Methodology: A hospital based prospective study conducted on 50 chronic hepatitis B infection with HbeAg antigen positive patients between age group 12 to 60 years, receiving tenofovir (300mg) was taken for study. HbeAg, HbsAg and liver enzyme status was checked at the end of 6 months and 12 months.
Results: ALT level became normal (<19mg/ml) in 37.5 % of female patients at the end of 12 months study and in male it was 67.65%. Overall biochemical response was 58%. All patients were HbeAg reactive at the end of 6 months of tenofovir therapy but 48 percent became non reactive at the end of 12 months. Overall seroconverson was 36 percent at the end of 12 months.
Conclusion: There is statistical significant number of HbeAg loss, normalization of ALT level and HbeAg seroconversion at the end of 1 year. HBV DNA level became undetectable level in all sero converted groups.
Keywords: Chronic hepatitis B; Tenofovir: Seroconverson.
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