The detection of uterine adnexal mass with associated raised serum CA 125 level is highly suspicious for ovarian cancer, but there are various other benign and malignant adnexal pathologies that mimic the above findings, especially in premenopausal women in our country as seen in our case study. The aims and objectives of this study were to study the histopathological spectrum of uterine adnexal mass and correlation of serum CA125 with benign & malignant masses, determine the incidence rate, age distribution and histopathological pattern of  adnexal mass in operated specimens, to study the frequency of benign and malignant neoplasms of ovary in this region and also to study the cut off values of Serum CA-125 in Benign and Malignant ovarian lesions. The present study had revealed various facets of epithelial ovarian tumours keeping comparable results with different studies. Among all cases 64.71% of the cases were benign, 5.88% borderline and 29.41% malignant. Benign tumours clustered a decade earlier than malignant tumours. The epithelial tumours are the most common tumours. Unless better methods of prevention, early diagnosis and/or curative treatment are introduced, a gradual rise in the mortality rate from uterine adnexal cancer, especially ovarian cancer is expected in this country.

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