Dengue is a potentially fatal acute febrile illness caused by infection with any of the four dengue viruses, DENV 1,2,3,4. Spectrum of disease may vary from asymptomatic infection to more fatal dengue haemorrhagic fever (DHF) and dengue stroke syndrome (DSS). Neurological manifestations of dengue can be seizures, encephalitis, meningitis, encephalopathy, stroke and Guillain barre syndrome. We report a case of 24 year old male who presented to us with fever and complex partial status epilepticus and was diagnosed as Dengue encephalitis.

Keywords: encephalopathy, stroke, seizures, neurological, DHF, DSS.

1. Deen JL, Harris E,Wills B, Balmaseda A, Hammond SN, Rocha C,Dung NM, Hung NT, Hien TT,Farrar JJ. Lancet. 2006; 369(9530):170-3
2. Soares C. N, Cabral-Castro M. J, Peralta J. M, de Freitas M. R, Zalis M, Puccioni-Sohler M. Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. J. Neurol. Sci. 2011;303: 75–79.
3. Srivastava V. K, Suri S, Bhasin A, Srivastava L, Bharadwaj M. An epidemic of dengue haemorrhagic fever and dengue shock syndrome in Delhi: a clinical study. Ann. Trop. Paed.1990; 10:329–334.
4. Soares C. N, Cabral-Castro M. J, Peralta J. M, Freitas M. R, Puccioni-Sohler M. Meningitis determined by oligosymp-tomatic dengue virus type 3 infection: report of a case. Int. J. Infect. Dis.2010;14:e150–e152.
5. Verma R, Sahu R, Singh A. S, Atam V. Dengue infection presenting as ischemic stroke: an uncommon neurological manifestation. Neurol. India 2013;61:317–318.
6. Seet R. C. S, Lim E. C. H. Dysarthria clumsy hand syndrome associated with dengue type-2 infection. J. Neurol. 2007;254:1129–1130.
7. Weeratunga P. N, Caldera H. P, Gooneratne I. K, Gamage R, Perera W. S, Ranasinghe G. V, et al. Spontaneously resolving cerebellar syndrome as a sequelae of dengue viral infection: a case series from Sri Lanka. Pract. Neurol.2014;14:176–178.
8. Mota M. T, Estofolete C. F, Zini N, Terzian A. C, Gongora D. V, Maia I. L, et al. Transverse myelitis as an unusual complication of dengue fever. Am. J. Trop. Med. Hyg.2017;96:380–381.
9. Fong C. Y, Hlaing C. S, Tay C. G, Kadir K. A, Goh K. J, Ong L. C. Longitudinal extensive transverse myelitis with cervical epidural haematoma following dengue virus infection. Eur. J. Paediatr. Neurol. 2016;20:449–453.
10. Viswanathan S, Botross N, Rusli B. N, Riad A. Acute disseminated encephalo-myelitis complicating dengue infection with neuroimaging mimicking multiple sclerosis: a report of two cases. Mult. Scler. Relat. Disord.2016;10: 112–115.
11. Umapathi T., Lim C. S., Ooi E. E., Zhang S. L., Goh E. J., Tan H. C., et al. Asymptomatic dengue infection may trigger Guillain-Barré syndrome. J. Peripher. Nerv. Syst.2016; 21:375–377.
12. Siriyakorn N, Insiripong S. Fatal rhabdomyolysis in dengue hemorrhagic fever: a case report. Southeast Asian J. Trop. Med. Public Health. 2015;46(Suppl. 1):149–152.
13. Maurya P. K, Kulshreshtha D, Singh A. K, Thacker A. K. Rapidly resolving weakness related to hypokalemia in patients infected with dengue virus. J. Clin. Neuromuscul. Dis.2016;18: 72–78.
14. Jain R. S, Gupta P. K, Agrawal R, Kumar S, Khandelwal K. An unusual case of dengue infection presenting with hypoka-lemic paralysis with hypomagnesemia. J. Clin. Virol.2015;69:197–199.
15. Verma R, Sharma P, Khurana N, Sharma L. N. Neuralgic amyotrophy associated with dengue fever: case series of three patients. J. Postgrad. Med.2011;57:329–331.
16. Peter S, Malhotra N, Peter P, Sood R. Isolated Bell's palsy-an unusual presentation of dengue infection. Asian Pac. J. Trop. Med.2013;6:82–84.
17. Yip V. C.-H., Sanjay S., Koh Y. T.. Ophthalmic complications of dengue fever: a systematic review. Ophthalmol. Ther.2012;1:1–19.
18. Daphale A, Acharya S, Shukla S, Lahoti S; Multiple cranial nerve involvement in case of dengue meningoencephalitis -A rare presesntation. International journal of medical science and clinical inventions 2017 4(1):2562-2565
19. Sanguansermsri T, Poneprasert B, Phornphutkul B. Acute Encephalopathy Associated with Dengue Infection. Bangkok: SEAMEO TROPMED. 1976; 10–11.
20. Sahu R, Verma R, Jain A, Garg R. K, Singh M. K, Malhotra H. S, et al. Neurologic complications in dengue virus infection: a prospective cohort study. Neurology.2014; 83:1601–1609.
21. Thisyakorn U, Thisyakorn C, Limpitikul W, Nisalak A. Dengue infection with central nervous system manifestations. Southeast Asian J. Trop. Med. Public Health.1999;30:504–506.
22. Chaturvedi U. C, Dhawan R, Khanna M, Mathur A. Breakdown of the blood—brain barrier during dengue infection of mice. J. Gen. Virol.1991;72:859–866.
23. Sharma C. M, Kumawat B. L, Ralot T, Tripathi G, Dixit S. Guillain Barre syndrome occurring during dengue fever. J. Indian Med. Assoc.2011;109:675–682.
24. Puccioni-Sohler M, Orsini M, Soares C. N. Dengue: a new challenge for neurology. Neurol Int.2012;4:e15.
25. Soares C. N, Faria L. C, Peralta J. M, de Freitas M. R, Puccioni-Sohler M. Dengue infection: neurological manifestations and cerebrospinal fluid (CSF) analysis. J. Neurol. Sci.2006;249:19–24.
26. Domingues Kuster GW, Onuki-Castro FL, Souza VA, Levi JE, Pannuti CS Involment of central nervous system in patients with dengue virus infection. J Neurol Sci 2008; 267:36-40.
27. Garg R. K, Rizvi I, Ingole R, Jain A, Malhotra H. S, Kumar N., et al. Cortical laminar necrosis in dengue encephalitis—a case report. BMC Neurol.2017;17:79.

Dr. Sourya Acharya

Prof. Dept of Medicine, J.N Medical College, DMIMS University, Sawangi (M), Wardha – 442001, Maharashtra, India

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