Chronic kidney disease (CKD) is a condition characterized by a gradual loss of kidney function for a long period of time. It is a worldwide public health problem with an increasing incidence and prevalence. If chronic kidney disease gets worse it may develop complications like high blood pressure, anaemia, lung disease and cardiovascular problems. The objective of this study was to find out mortality rate in nephrology department and to observe the major co-morbid conditions leading to progression of chronic kidney disease and end stage renal disease. A total of 480 patients diagnosed with CKD were enrolled in the study and we observed mortality in 80 patients (16.6 %) and the highest prevalence was observed in age group of 51- 60 years. In our study, majority of the mortality cases were observed in patients with diabetes and hypertension. 85 % of patients were on haemodialysis; among them most of the patients were rural residents. This study concludes that CKD is also one of the leading causes of mortality. Central and state authorities must take necessary steps in creating awareness and increase dialysis centres at the rural level, which will significantly reduce the mortality rate and improve quality of life.

Keywords: Chronic kidney disease (CKD), Mortality, Haemodialysis, Co-morbid conditions.

1. Robert Thomas, Abbas Kanso, John R. Sedor. Chronic Kidney Disease and Its Complications. Prim Care Clin Office Pract 35 (2008) 329–344.
2. Definition of CKD and classification of CKD stage. 2008 Sep; 66(9): 1645-9. Available from www.ncbi.nlm.nih.gov/pubmed/18788389
3. Joseph T. Dipiro, Robert L. Talbert, Pharmacotherapy A Pathophysiologic Approach. Seventh Edition. Chapter 46. Chronic kidney disease: progression-modifying therapies: Pg 747,748.
4. Radica Z. Alicic, Michele T. Rooney, and Katherine R. Tuttle, Diabetic Kidney Disease: Challenges, Progress, and Possibilities. Clin J Am Soc Nephrol 13:volume 3: 2017.
5. Leticia Buffet, Charlotte Ricchetti, Chronic Kidney Disease and Hypertension: A Destructive Combination: US Pharm. 2012; 37(6):26-29.
6. Tattersall J, Dekker F, Heimburger O, et al. When to start dialysis: updated guidance following publication of the Initiating Dialysis Early and Late (IDEAL) study. Nephrol Dial Transplant. 2011, 26:2082-2086. 10.1093/ndt/gfr168.
7. Wang H, Naghavi M, Allen C, et al., Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016: 388:1459–544.
8. Jha V, Garcia-Garcia G, Iseki K, et al. Chronic kidney disease: global dimension and perspectives. Jul 20 2013: 382(9888): 260-272.
9. Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major non communicable diseases. Kidney Int. Dec 2011: 80(12): 1258-1270.
10. Maria do Sameiro-Faria, Sandra Ribeiro, Elísio Costa, et al., Risk Factors for Mortality in Hemodialysis Patients: Two-Year Follow-Up Study. Disease Markers. Volume 35 (2013), Issue 6, Pages 791–798.
11. Mohamed Elhafiz Elsharif. Mortality Rate of Patients with End Stage Renal Disease on Regular Hem dialysis: A Single Center Study. Saudi J Kidney Dis Transpl 2011: 22(3): 594-596.
12. Anna J Dare, Sze Hang Fu, Jayadeep Patra, Peter S Rodriguez et al,. Renal failure deaths and their risk factors in India 2001–13: nationally representative estimates from the Million Death Study. Lancet Glob Health 2017: 5: e89–95 Vol 5.
13. Tamiru Shibiru, Esayas Kebede Gudina, Belete Habte, Amare Deribew and Tewodros Agonafer, Survival patterns of patients on maintenance hemodialysis for end stage renal disease in Ethiopia. Shibiru et al. BMC Nephrology 2013, 14:12.
14. Percy Herrera-Anazco, Vicente Benites-Zapata, Adrian V. Hernandez, Edward Mezones Holguin, Manuela Silveira-Chau, Mortality in patients with chronic kidney disease undergoing haemodialysis in a public hospital of Peru. J Bras Nefrol 2015: 37(2): 192-197.
15. Al Wakeel JS, Mitwalli AH, Al Mohaya S, Abu-Aisha H, Tarif N, Malik GH,  Hammad D. Morbidity and mortality in ESRD patients on dialysis. Saudi j kidney dis transpl 2002 October-December: 13(4): 473-7.
16. Stephanie Toth- Manikowski and Mohamed G. Atta Diabetic kidney disease: Pathophysiology and therapeutic targets. Journal of diabetes research volume 2015, Article ID 697010: 1-16.
17. United States Renal Data System: USRDS 1998 Annual Data Report. Bethesda, National Institutes of Health, Diabetes and Digestive and Kidney Diseases, April, 1998.
18. Kim SG, Kim NH. The effect of residual renal function at the initiation of dialysis on patient survival. Korean J Intern Med 24: 2009, 55-62.
19. Chang JH, Rim MY, Sung J, et al. Early start of dialysis has no survival benefit in end-stage renal disease patients. J Korean Med Sci 27: 2012, 1177-1181.
20. Orth S.R. Smoking a renal risk factor Nephron 86: 2000, 12–26.

S. Umar Farooq

Department of Pharmacy Practice, Care College of Pharmacy, Oglapur (V), Damera (M), Warangal (Rural), Telangana- 506006, India

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