Objectives: The single nucleotide polymorphism (SNP) at Trp53arg72 pro genotypes is found to be associated with breast cancer, with variable results, the aim of this study is to evaluate the frequency of   SNP at Trp 53 codon 72 and its association with breast cancer in north Indian population.

Methods: 30 patients with breast cancer were compared with 30 controls. Genotype and allele distribution of Trp53 codon 72 where determined using polymerase chain reaction- restriction fragment length polymorphism method.

Results: The genotypic distribution of arg/arg, arg/pro, pro/pro among cancer patients vs  controls were 53.33%, 33.33%, 13.33% and 56.7%, 26.7%, 16.7% respectively (p=0.83).

Conclusion: though the difference in genotypic distribution was not significant, we found in the higher number of heterozygous genotypes (arg/pro) in cancer tissue suggesting, heterozygous (arg/pro) genotype may predispose women to breast cancer. This necessitates conducting the study including more patients.

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