Aim & Objective: Adipose cells release various adipocytokinins in response to insulin resistance. The purpose of this study was to investigate any significant difference in the level of total serum adiponectin and its association with fasting insulin, and fasting serum glucose levels, which are predictors of diabetes.

Material and Methods: An analytical cross sectional study with 120 subjects (60 normal healthy off-springs of diabetic parents and 60 normal healthy off-springs of non-diabetic parents) between age group of 18 to 30 years. Subjects were enrolled after applying all inclusion and exclusion criteria and written informed consent were taken. All socio-demographic data of the participants were entered in a self-designed questionnaire. Serum adiponectin was done by ELISA and fasting glucose by glucose peroxidise method.

Results: The mean value of Fasting Blood Sugar in offspring of non-diabetic, single diabetic parent and both diabetic parents were 85.23(SD 5.939), 86.84(SD 6.258) and 94.95(SD 6.586). The mean value of serum adiponectin found significantly lower in offspring of both diabetic parents than offspring of single diabetic parent (0.039*) and offspring of non-diabetic parents (0.000**).

Conclusion: Adiponectin has been reported as a new risk factor for the development of diabetes. When both parents are diabetic their offsprings should always be kept in follow up as they have high chances of developing hyperglycemia.

Keywords: Adiponectin, Diabetes, Insulin.

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Rohit Manyal

Department of Biochemistry, MGM Medical College Indore, MP India

Mob: 07000786450, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.