Title: Serum Fibrinogen Level in COPD Patients- A Comparative Study
Authors: Agale S A, Pujari VV, Chopra R K
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.116
Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) is now the third most common cause of death in the world. The severity and progression of COPD is measured by forced expiratory volume in 1 second (FEV1). However, FEV1 may not be an ideal surrogate for short-term drug trials. Biomarkers like Fibrinogen, CRP etc could become suitable surrogates in the early detection of disease.
Aims & objectives: To study the association of blood fibrinogen level in COPD and its correlation with the severity of COPD
Methodology: this study was conducted on 50 stable COPD patients and a control group of 50 healthy persons. After the thorough history and clinical examination, all the subjects were investigated with complete Blood Count, chest radiographs, spirometry and serum Fibroinogen levels.
Results: Mean age in test group was 63.16 yr and in control group was 59.86 years. Mean WBC count in the test group was 8795/cmm and in Control group was 6020 /cmm (p<0.0001). Mean fibrinogen level in the test group was 455.38 mg% and in control group was 255.50 mg% (p<0.0001). Fibrinogen levels correlate with severity of COPD
Conclusion: Serum fibrinogen levels can be used as a biomarker in the COPD which correlates with the disease severity.
Keywords: COPD, FEV1, Serum Fibrinogen.
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