Background & Objective: Cerebral venous sinus thrombosis (CVST) remains a diagnostic & therapeutic challenge for the clinician. This study analyses the epidemiological factor, clinical profile, predisposing factor & radiological characteristics of 41 patients of radiological confirmed cases of CVST.

Method: This study comprises 41 consecutive patients with radiologically confirmed diagnosis of CVST who were admitted to a tertiary care hospital in western Odisha for the period from January 2014 to February 2017.The diagnosis was confirmed by MRI Brain & MR Venography. The epidemiological, clinical & radiological, laboratory evaluation done & datas were recorded in a structured proforma.

Result: Total number of patients were 41.Female outnumbered males in the ratio of 29:12.The mean age of presentation was 32.1(age range 15-66 years).The most frequent predisposing factor was OCP use in females & infection & alcoholism in males. The mean duration of symptoms before presentation was 7 (+/- 3.1) days. Most common presenting feature was headache. Transverse sinus sinus was most commonly involved followed by Superior sagital sinus.

Conclusion: CVST presents with varied symptom & sign. Females were mostly affected. Headache was the most frequent symptom. OCP use in females & infection in males were the most common presenting feature.

1. Ehtisam A, Stern BJ. Cerebral venous thrombosis: A review Neurologist 2006;12:32-8
2. Yadollahikhales G, Borhani-Haghighi A, Safari A, Wasay M, Edgell R  Cerebral venous sinus thrombosis. GMJ 2016;5 Suppl 1;48-61.
3. Dash D, Prasad K, Joseph L. Cerebral venous thrombosis; An Indian perspective. Neurology India 2015;63:318-28
4. Padmavati S,Gupta S,Singh B. A clinical study of 44 cases of hemiplegia of adult women. Neurology India 1957;5:59-65.
5. Nagpal RD. Dural sinus and cerebral venous thrombosis. Neurosurgery Rev 1983;6:155-60
6. Srinivasan K, Natarajan M. Cerebral venous and arterial thrombosis in pregnancy and puerperium.Neurol India 1974;22:131-40
7. Srinivasan K, Natarajan M. Crebral venous and sinus thrombosis in pregnancy and ppuerperium. A study of 135 patients. Angiology 1983;34:731-46.
8. Nagaraja D, Taly AB. Cerebral venous thrombosis. J Assoc Physicians India 1987;35:876.
9. Narayan D,Kaul S,Ravishankar K, Suryaprabha T, et al. Risk factors, clinical profile, and long term outcome of 428 patients of cerebral sinus venous thromb-osis: Insights from Nizams Institute Venous stroke Registry, Hyderabad (India). Neurol India 2012;60:154-9.
10. Ferro JM,Canhao P,Stam J, Bousser MG, Barinagarrementeria F, ISCVT Investigators. Prognosis of cerebral vein and Dural Sinus Thrombosis: Result of the International study on Cerebral vein and Dural Sinus Thrombosis (ISCVT). 2004;35:664-70
11. Ferro JM,Correia M, Pontes C, Baptista MV,Pita F, Cerebral venous thrombosis Potuguese collaborative study group (venoport). Cerebral vein and dural sinus thrombosis in Portugal:1980-88. Cerebro-vasc Dis 2001;11:177-82.
12. Kalita J, Chandra S, Mishra UK. Significance of seizure in cerebral venous sinus thrombosis. Seizure 2012;21:639-42.
13. Nagaraja D, Wassy M, Christophor M, Santosh V. Cerebral venous sinus Thrombosis. In Chopra JS, Sawhney IMS editor. Neurology in Tropics, 2^nd Elsevier, 2016;669-679.
14. Caso V, Agnelli G, Paciaroni M, editors. Hand book on cerebral venous thrombosis. Karger Medical and Scientific  Publishers; 2008,23-54.
15. Khealani BA, Wasay M, Saadah M, Sutana E, Mustafa S, Khan FS, et al Cerebral venous thrombosis; A descriptive multicenter study of patients in Pakistan and Middle East. Stroke 2008;39:2707-11.
16. Pai N, Ghosh K, Shetty S. Hereditary  thrombophillia in cerebral venous thrombosis; A  study from India. Blood Coagul Fibrinolysis 2013;24: 540-3.
17. Felicio AC, Fukujima AM, Fiorot JA jr, do Prado GF, et al. Cerebral venous thrombosis and Hepatitis: case report. Arq Neuropsiquiatr 2006;64:1041-42.
18. Kesler A, Pomeranz IS, Huberman M, etal. Cerebral venous  thrombosis  and chronic active  hepatitis as part of the antiphospholipid syndrome. Postgrad Med J 1996;72:690-92.
19. Algherbawe MT, Khan FY, Abonoff SS, et al. Clinical charecteristics and outcome of cerebral venous thrombosis: A 4- year Hospital based study from 2008 to 2011. Libyan J Med Sci 2017;1:36-9.
20. Wasay M, Azeemuddin M. Neuroimaging of cerebral venous Thrombosis. J Neuroimaging.2005;15:118-128.

Prof Prativa Panda

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