Title: Evaluation of Bronchodilator Activity of Siddha Herbo Mineral Drug “Vasanthakusumakara Mathirai” by Exposing Guinea Pig in Histamine Aerosol
Authors: Dr M. Indhumathi, Dr A.Shanuvas, Dr V.Velpandian M.D., Ph.D
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.63
Abstract
Asthma is an inflammatory disease of the small airways characterized by episodic, reversible bronchial obstruction, polyphonic wheeze, dyspnoea, and cough which may be relieved spontaneously or as a result of therapy. Asthma cannot be cured but it could be controlled. Combined medications possess both reliever and controller properties are very good for asthmatic treatment. Siddha herbo mineral preparations are bio-safe and have its own fast acting properties to control broncho constriction and relieves from asthmatic symptoms early. And they probably don’t cause any adverse drug reactions. Vasanthakusumakara Mathirai (VKM) was indicated for respiratory illness includes sneezing, fever and bronchial asthma. To evaluate the Siddha herbo mineral drug VKM by exposing guinea pig in histamine aerosol for bronchodilator activity. Four group each group contain six animal. All the doses were given orally once a day for 5 days. Prior to drug treatment each animal was placed in the histamine chamber and exposed to 0.2 % histamine aerosol. The pre convulsive time (PCT) was determined from the time of exposure to onset of convulsions. These animals were again subjected to histamine aerosol after 1hour of drug administration and PCT was determined, then results were tabulated. Hence the test drug has significant effect on bronchodilator and proves to be the best drug for treating asthma.
Keyword: Bronchodilator, Vasanthakusumakara Mathirai, Siddha, Pre-convulsion time.
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