Title: Cardiovascular effects of methylphenidate in children with attention deficit hyperactivity disorder (ADHD)
Authors: Pramesh Dogra, Sunita Mondal, Rajiv Bandhu, Dinesh Kataria, Om Sai Ramesh V
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.39
Abstract
The present study was conceived with the objective to examine the effects of methylphenidate on cardiovascular variables in children with Attention-deficit/hyperactivity disorder (ADHD). ECG indices plus systolic blood pressure (SBP), diastolic BP (DBP) and heart rate (HR) were assessed in 52 children with ADHD (dosage of 0.3- 1 mg/ kg body weight). Cardiovascular parameters were assessed at baseline and 12 weeks. Small but statistically significant changes in DBP and HR were observed at 12 weeks without clinically meaningful changes in ECG. Increase in heart rate and Blood pressure could be attributed to the increased sympathetic activity caused by methylphenidate.
Keywords: methylphenidate, ADHD, Cardiovascular effects.
References
- Thomas R, Sanders S, Doust J, Beller E, Glasziou P. Prevalence of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. Pediatrics. 2015 Apr 1;135(4):e994-1001.
- Sadock BJ, Sadock VA. Attention-Deficit Disorders. In: Sadock BJ, Sadock VA editors, Kaplan and Sadock’s Comprehensive Textbook of Psychiatry, 9th ed. Philadelphia: Lippincott Williams and Wilkins; 2009. p.3560-618.
- Wilens TE. Mechanism of action of agents used in attention-deficit/hyperactivity disorder. J Clin Psychiatry 2006;67:32-8.
- Greenhill L, Beyer DH, Finkleson J, Shaffer D, Biederman J, Conners CK, Gillberg C, Huss M, Jensen P, Kennedy JL, Klein R. Guidelines and algorithms for the use of methylphenidate in children with Attention-Deficit/Hyperactivity Disorder. Journal of attention disorders. 2001 Dec;6: S89-100.
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorder, 5then. Washington, DC: American Psychiatric Publishing; 2013. P. 314-26
- Bange F, Le Heuzey MF, Acquaviva E, Delorme R, Mouren MC. Cardiovascular risks and management during Attention Deficit Hyperactivity Disorder treatment with methylphenidate. Archives de pediatrie: organeofficiel de la Societe Francaise de pediatrie. 2014 Jan;21(1):108-12.
- Aman MG, Werry JS. The effects of methylphenidate and haloperidol on the heart rate and blood pressure ofhyperactive children with special reference to time of action. Psychopharmacology. 1975 Jan 1;43(2):163-8.
- Garg J, Arun P, Chavan BS. Comparative short term efficacy and tolerability of methylphenidate and atomoxetine in attention deficit hyperactivity disorder. Indian pediatrics. 2014 Jul 1;51(7):550-4.
- Arcieri R, Germinario EA, Bonati M, Masi G, Zuddas A, Vella S, Chiarotti F, Panei, and the Italian Attention-Deficit/Hyperactivity Disorder Regional Reference Centers P. Cardiovascular measures in children and adolescents with attention-deficit/hyperactivity disorder who are new users of methylphenidate and atomoxetine. Journal of child and adolescent psychopharmacology. 2012 Dec 1;22(6):423-31.