Amniotic epithelial cells are generated from amnioblasts on the eighth day after fertilization and constitute the inner layer of the amnion. Many studies have demonstrated the differentiation potential of human amniotic epithelial cells (HAEC)into cells of all three germ layers. Its easy accessibly without any ethical constrains has made it an ideal non-controversial source of primary cells that can be differentiated in a plethora of organ specific lineages. The aim of this review is to highlight the versatility of hAECs whilst exploring its tri-lineage differentiation potential. Which makes these cells an ideal candidate for disease modeling and cellular replacement therapy.

Keywords: Amniotic epithelial cells, cellular replacement therapy, disease modeling.

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D.Hettiaracchchi

Human Genetics Unit, Faculty of Medicine, University of Colombo, Sri Lanka