Title: Correlation between Statin use and Intracranial Haemorrhage
Authors: Dr Sriharsha Kulkarni, Dr Muralidhar.H
DOI: https://dx.doi.org/10.18535/jmscr/v6i5.141
Abstract
Background: Intracerebral haemorrhage (ICH) is a neurologic injury resulting in significant morbidity and mortality. Statins play a significant role in primary and secondary prevention of cardiovascular and cerebrovascular ischemic events. Despite clear benefits of statins in ischemic stroke, studies suggest there may be a link between statin therapy and development of ICH.
Aims and Objectives: To find the correlation between statin use and intracranial haemorrhage.
Methods and Results: Retrospective study among 50 patients with intracranial haemorrhage. Detailed history including co-morbid conditions (especially HTN and IHD), intensity of statin used, severity of IC bleed, fasting lipid and GCS were obtained and analysed. IC bleed was classified into mild (less than 30cc), moderate (30 to 100cc) and severe (more than 100cc) based on volume of IC bleed on CT brain. Correlation was obtained between statin use and intracranial haemorrhage.
Results and Conclusion: The study found out that statin users had larger bleed volume, low GCS, lower total cholesterol and LDL levels. Also observed in the study was higher the intensity of statins more severe is the IC bleed. IC bleed also correlated with higher age, male sex, hypertension and IHD.
Keywords: Statins, Intracranial Haemorrhage, Intracerebral Haemorrhage.
References
- Westover MB, Bianchi MT, Eckman MH, Greenberg SM. Should Statins be Avoided after Intracerebral Hemorrhage ?. Arch Neurol. 2011;68(5):573–9.
- Stancu C, Sima A. Statins: mechanism of action and effects. J Cell Mol Med. 2001;5(4):378-87.
- Caceres JA, Goldstein JN. Intracranial Hemorrhage. Emerg Med Clin North Am. 2012;30(3):771–94.
- Matre ETV, Sherman DS, Kiser TH. Management of Intracerebral haemorrhage – use of statins. Vascular Health and Risk Management. 2016;12:153–61.
- Siddiqui FM, Langefeld CD, Moomaw CJ, Comeau ME, Sekar P, Rosand J et al. Use of Statins and Outcomes in Intracerebral Hemorrhage Patients. 2017;48 (8):1-7.
- Tai S, Lin F, Lee C, Chang C, Wu M, Chien C. Statin use after intracerebral hemorrhage: a 10-year nationwide cohort study. Brain and Behavior. 2016;6(8):1-10.
- Goldstein LB. Statin Therapy Should be Discontinued in Patients With Intracer-ebral Hemorrhage. Stroke.2013;44:2058-9.