A series of N-alkyl benzimidazol piperazine fluoroquinolines with remarkable improvement in antimicrobial activity as compared to the moxifloxacin were synthesized and characterized by ¹HNMR, ¹³C NMR, IR, Mass and elemental analysis. These derivatives were evaluated for their invitro activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. The results showed that all the synthesized derivatives of novel fluoroquinolines possess antimicrobial activity. However, compound derivatives IV and V3 have antibacterial activities against Pseudomonas, Klebsiella and Staphylococcus epidermidis. Among all these derivatives, compound V3 exhibit potent inhibitory activity with MIC of 19 µg/mL. 

Keywords: N-alkylbenzimidazolpiperazinefluoroquinolines, antimicrobial activity, MIC.

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Prita S. Borkar

Department of Microbiology, NES Science College,

Nanded, Maharashtra, India-431605