Aim: Vitamin D deficiency is one of the major health problems in all age groups especially in elderly women. Menopause marks an important change in woman’s life. With an increasing age, women are at high risk of several metabolic diseases. Therefore, the aim of this study is to find the status of serum vitamin D and hs-CRP in pre- and postmenopausal women.

Methods: Total 500 female subjects were taken, out of which 400 pre- & postmenopausal women were considered as cases while 100 subjects were considered as control healthy women. Serum Vitamin D was estimated by chemiluminescent micro particle immunoassay method while hs-CRP was assayed in serum by using latex-enhanced turbidimetric immunoassay method. Serum Estradiol (E₂) was estimated by competitive immunoassay method in all studied female subjects. Data were analyzed by using SPSS software, version 22.0.

Result: Serum Vitamin D levels were significantly decreased while hs-CRP was significantly increased (p<0.001) in pre- and postmenopausal women as compared with control healthy women. Serum estradiol was also significantly decreased in postmenopausal women. We also found a significant negative correlation between vitamin D deficiency and hs-CRP levels in both pre- and postmenopausal women.

Conclusion: Postmenopausal women at increased risk of vitamin D deficiency as compared to premenopausal women. Low-grade systemic inflammation precedes the risk of CVD, diabetes and metabolic syndrome in postmenopausal women.

Keywords: Vitamin D, hs-CRP, Estradiol, premenopausal, postmenopausal women.

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Deepa Gupta

Department of Biochemistry, G. R. Medical College, Gwalior (M.P.), India

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