Title: Clinical and Laboratory Profile of Type 2 Diabetic Patients with Asymptomatic Bacteriuria
Authors: Raju Vijai Usha Raj, Rajalakshmi K V, Aruna Sekhar, Palani Kannan
DOI: https://dx.doi.org/10.18535/jmscr/v6i5.77
Abstract
Background: Diabetes leads to several abnormalities of the host defence system that may result in higher risk of certain infection including UTI [2]. These include immunologic impairment such as impaired migration, intra cellular killing, phagocytosis, chemotaxis of polymorpho nuclear leukocytes from diabetic patients[3] and neuropathic complications such as impaired bladder emptying[4].
Aim: The aim of the study was to study the prevalence of asymptomatic bacteriuria in diabetics and non diabetics age <45 years and to study the clinical and laboratory parameters in patients with asymptomatic bacteriuria.
Materials and Methods: A cross sectional comparative study in 90 diabetics and 90 non-diabetics. During initial visit relevant details and history regarding the patients are collected like age, duration of diabetes, medications, pregnancy, history of hospitalisation, catheterization, surgery, history pertaining to urinary symptoms and gynaecological infections like dysuria, frequency of micturition, history of white discharge, pruritis vulva. Relevant investigations like fasting and post prandial sugar , urine analysis, urine culture and sensitivity, renal function tests, ultra sound for PVR, urine microalbuminuria, screening for diabetic retinopathy and neuropathy to be carried out (Questionnaire attached).
Results: In our study the prevalence of Asymptomatic bacteriuria in diabetic patients ≤45 years is 21.1%. There was no significant correlation between Asymptomatic bacteriuria and post void residual urine.
Conclusion: There was significant association between Asymptomatic bacteriuria and retinopathy. There was no association between Asymptomatic bacteriuria and peripheral neuropathy, IHD, CAD, peripheral vascular disease and nephropathy. There was significant association between poor glycemic control, duration of diabetes and Asymptomatic bacteriuria signifying the importance of metabolic control.
Keywords: Asymptomatic bacteriuria, Post voidal urine, Body mass index, Type2 Diabetes mellitus, Ischemic heart disease, Colony forming units, Coronary artery disease.
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