Aim: Liver is the vital organ regarding energy metabolism. Alteration of liver enzymes may be one of the risk factor for altered glucose metabolism. This study aim is to analysis metamorphic changes in liver enzymes in prediabetic young adult subjects.  

Methods: Total 400 subjects were taken, out of which 300 were diagnosed prediabetic subjects while 100 are normal healthy age and gender match controls (normoglycemic).The anthropometric parameters were measured by standard methods. The serum samples were used for glucose, AST, ALT, ALP and GGT estimation by mindray BS-400 autoanalyser. The plasma HbA1c estimated by boronate affinity chromatography.

Results: the prediabetic subjects had higher WC, WHR, BMI, blood pressure, serum AST, ALP and GGT as compared to normoglycemic subjects.

Conclusion: The altered liver enzymes (serum AST, ALP and GGT) may be associated with altered glucose homeostasis. Liver enzymes may be used as a cheap and reliable marker in prediabetes subjects. Proper and timely management of prediabetes may prevent the various complications which may appears in future.

Keywords:  Prediabetes, liver enzymes, young adult, GGT, ALT.

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Ashish Kumar Sharma

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