Title: Comparative Study of High Sensitivity C-Reactive Protein with Body Mass Index in a Population of Alappuzha, Kerala
Authors: Dr Sunayana Mathew, Dr Rose Davy.C, Dr Deepa Rajendran
DOI: https://dx.doi.org/10.18535/jmscr/v6i4.141
Abstract
Background: High-sensitivity C-reactive protein (hs-CRP) is known as a marker for low-grade inflammation and atherosclerosis. Due to its cardiovascular risk owing to atherosclerosis, its possible correlation with obesity in a local population was assessed, using BMI as the parameter.
Objective: To study correlation of hs-CRP with BMI in a population of 25-45 years in Alappuzha, Kerala.
Materials & Methods/Procedure: 111 subjects of either sex, with no history of coronary artery disease, ongoing systemic illnesses or steroid treatment, were selected; BMI and serum fasting levels of hs-CRP taken; arbitrarily divided into three groups, having hs-CRP levels (i)<1 mg/l, (ii)1-3 mg/l, and (iii)>3 mg/l, and the Mean BMI in each group calculated.
Results: There was significant association between BMI and hs-CRP in both males (F= 13.53;p<0.01) and females(F=15.01;p<0.01). Correlation between the same parameters indicated that there was positive correlation (r=0.054;p<0.01).
Conclusions/Implications: Further, longitudinal studies can done to estimate the role of dietary factors and chronic effect of anti-inflammatory medications on hs-CRP and BMI respectively.
Keywords:High Sensitivity C-Reactive Protein, Body Mass Index, Atherosclerosis, Coronary Artery Disease
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