Background and Aim: Postoperative nausea and vomiting (PONV) is commonly seen after laparoscopic surgery. In this randomized double blind prospective clinical study, we investigated and compared the efficacy of palonosetron with dexamethasone and ondensetron with dexamethasone to prevent postoperative nausea and vomiting after laparoscopic cholecystectomy.

Materials and Method: Sixty patients (18-60 yrs of age) undergoing elective laparoscopic cholecystectomy were randomly allocated one of the two groups containing 30 patients each. Group 1 received ondensetron 4 mg and dexamethasone 8 mg intravenously as a bolus before induction of anaesthesia. Group 2 received palonosetron 0.075 mg and dexamethasone 8 mg intravenously as a bolus before induction.

Result: The incidence of a complete response (no PONV, no rescue medication) during post operative period is 86.6%,86.6%,93.4% and 93.4% in palonosetron group in 0-4,4-12,12-24 and 24-48 hrs respectively in comparison to ondensetron group in which 50%,63.34%,90% and 93.3%.

Conclusion: Prophylactic therapy with palonosetron is more effective than ondensetron for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.

Keywords: Palonosetron, Ondensetron, Postoperative Nausea and Vomiting (PONV), Laparoscopic surgery.

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Anita Pareek

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